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Santa-Maria, Cesar A.; Coughlin, Janelle W.; Sharma, Dipali; Armanios, Mary; Blackford, Amanda L.; Schreyer, Colleen; Dalcin, Arlene; Carpenter, Ashley; Jerome, Gerald J.; Armstrong, Deborah K.; Chaudhry, Madhu; Cohen, Gary I.; Connolly, Roisin M.; Fetting, John; Miller, Robert S.; Smith, Karen L.; Snyder, Claire; Wolfe, Andrew; Wolff, Antonio C.; Huang, Chiung-Yu; Appel, Lawrence J.; Stearns, Vered

The Effects of a Remote-based Weight Loss Program on Adipocytokines, Metabolic Markers, and Telomere Length in Breast Cancer Survivors: the POWER-Remote Trial

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  • Media type: E-Article
  • Title: The Effects of a Remote-based Weight Loss Program on Adipocytokines, Metabolic Markers, and Telomere Length in Breast Cancer Survivors: the POWER-Remote Trial
  • Contributor: Santa-Maria, Cesar A.; Coughlin, Janelle W.; Sharma, Dipali; Armanios, Mary; Blackford, Amanda L.; Schreyer, Colleen; Dalcin, Arlene; Carpenter, Ashley; Jerome, Gerald J.; Armstrong, Deborah K.; Chaudhry, Madhu; Cohen, Gary I.; Connolly, Roisin M.; Fetting, John; Miller, Robert S.; Smith, Karen L.; Snyder, Claire; Wolfe, Andrew; Wolff, Antonio C.; Huang, Chiung-Yu; Appel, Lawrence J.; Stearns, Vered
  • imprint: American Association for Cancer Research (AACR), 2020
  • Published in: Clinical Cancer Research
  • Language: English
  • DOI: 10.1158/1078-0432.ccr-19-2935
  • ISSN: 1078-0432; 1557-3265
  • Origination:
  • Footnote:
  • Description: <jats:title>Abstract</jats:title> <jats:sec> <jats:title>Purpose:</jats:title> <jats:p>We initiated a clinical trial to determine the proportion of breast cancer survivors achieving ≥5% weight loss using a remotely delivered weight loss intervention (POWER-remote) or a self-directed approach, and to determine the effects of the intervention on biomarkers of cancer risk including metabolism, inflammation, and telomere length.</jats:p> </jats:sec> <jats:sec> <jats:title>Experimental Design:</jats:title> <jats:p>Women with stage 0–III breast cancer, who completed local therapy and chemotherapy, with a body mass index ≥25 kg/m2 were randomized to a 12-month intervention (POWER-remote) versus a self-directed approach. The primary objective was to determine the number of women who achieved at least 5% weight loss at 6 months. We assessed baseline and 6-month change in a panel of adipocytokines (adiponectin, leptin, resistin, HGF, NGF, PAI1, TNFα, MCP1, IL1β, IL6, and IL8), metabolic factors (insulin, glucose, lipids, hs-CRP), and telomere length in peripheral blood mononuclear cells.</jats:p> </jats:sec> <jats:sec> <jats:title>Results:</jats:title> <jats:p>From 2013 to 2015, 96 women were enrolled, and 87 were evaluable for the primary analysis; 45 to POWER-remote and 42 to self-directed. At 6 months, 51% of women randomized to POWER-remote lost ≥5% of their baseline body weight, compared with 12% in the self-directed arm [OR, 7.9; 95% confidence interval (CI), 2.6–23.9; P = 0.0003]; proportion were similar at 12 months (51% vs 17%, respectively, P = 0.003). Weight loss correlated with significant decreases in leptin, and favorable modulation of inflammatory cytokines and lipid profiles. There was no significant change in telomere length at 6 months.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions:</jats:title> <jats:p>A remotely delivered weight loss intervention resulted in significant weight loss in breast cancer survivors, and favorable effects on several biomarkers.</jats:p> </jats:sec>
  • Access State: Open Access