Media type: E-Article Title: Biomarkers for EGFR-Antagonist Response: In the Genes and on the Genes! Contributor: Easwaran, Hariharan; Baylin, Stephen B. Published: American Association for Cancer Research (AACR), 2012 Published in: Clinical Cancer Research, 18 (2012) 8, Seite 2121-2123 Language: English DOI: 10.1158/1078-0432.ccr-12-0157 ISSN: 1078-0432; 1557-3265 Keywords: Cancer Research ; Oncology Origination: Footnote: Description: Abstract Patients with non–small cell lung carcinoma containing epidermal growth factor receptor (EGFR)–activating mutations benefit from EGFR-antagonist therapy. EGFR-antagonist sensitivity is also correlated with epithelial–mesenchymal transition, which Walter and colleagues show to be marked by DNA-methylation changes. If validated, these markers could help identify patients with wild-type EGFR who will benefit from EGFR therapy. Clin Cancer Res; 18(8); 2121–3. ©2012 AACR. Access State: Open Access