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Baty, Florent; van Gestel, Arnoldus J.R.; Kern, Lukas; Brutsche, Martin H.

Oxygen Uptake Recovery Kinetics after the 6-Minute Walk Test in Patients with Chronic Obstructive Pulmonary Disease

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  • Media type: E-Article
  • Title: Oxygen Uptake Recovery Kinetics after the 6-Minute Walk Test in Patients with Chronic Obstructive Pulmonary Disease
  • Contributor: Baty, Florent; van Gestel, Arnoldus J.R.; Kern, Lukas; Brutsche, Martin H.
  • imprint: S. Karger AG, 2016
  • Published in: Respiration
  • Language: English
  • DOI: 10.1159/000452307
  • ISSN: 0025-7931; 1423-0356
  • Keywords: Pulmonary and Respiratory Medicine
  • Origination:
  • Footnote:
  • Description: <jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;/i&gt;&lt;/b&gt; There is a growing interest in exercise parameters capable of objectively evaluating the functional capacity of patients with chronic obstructive pulmonary disease (COPD). &lt;b&gt;&lt;i&gt;Objectives:&lt;/i&gt;&lt;/b&gt; The purpose of the present study was to analyze breath-by-breath cardiopulmonary and gas exchange recovery responses of patients with COPD after a 6-minute walk test (6MWT). &lt;b&gt;&lt;i&gt;Methods:&lt;/i&gt;&lt;/b&gt; Oxygen uptake (VO&lt;sub&gt;2&lt;/sub&gt;) kinetics of patients were obtained using mobile telemetric cardiopulmonary monitoring during and after a 6MWT. Recovery kinetics were modelled using a 4-parameter nonlinear logistic model. Multiple linear regression was performed to assess the association between the half-time of recovery of oxygen consumption (T&lt;sub&gt;1/2&lt;/sub&gt; VO&lt;sub&gt;2&lt;/sub&gt;) and exercise capacity (6-minute walking distance, 6MWD). &lt;b&gt;&lt;i&gt;Results:&lt;/i&gt;&lt;/b&gt; Sixty-nine patients with COPD (28 females) with a mean age of 65 ± 10 years took part in the study. After adjustment for covariates (body mass index, forced expiratory volume in 1 s, forced vital capacity, and age), T&lt;sub&gt;1/2&lt;/sub&gt; VO&lt;sub&gt;2&lt;/sub&gt; was significantly associated with 6MWD (&lt;i&gt;p&lt;/i&gt; = 0.002). &lt;b&gt;&lt;i&gt;Conclusions:&lt;/i&gt;&lt;/b&gt; T&lt;sub&gt;1/2&lt;/sub&gt; VO&lt;sub&gt;2&lt;/sub&gt; can be used to reflect exercise capacity in patients with COPD. As T&lt;sub&gt;1/2&lt;/sub&gt; VO&lt;sub&gt;2&lt;/sub&gt; mostly depends on the rate of increase in pulmonary blood flow, the results of the present study underline the importance of cardiocirculatory impairment for exercise intolerance in patients with COPD.</jats:p>