Glahn, Alexander;
Rhein, Mathias;
Frieling, Helge;
Schuster, Rilana;
El Aissami, Alain;
Bleich, Stefan;
Hillemacher, Thomas;
Muschler, Marc
Smoking and Promoter-Specific Deoxyribonucleic Acid Methylation of the Atrial Natriuretic Peptide Gene: Methylation of Smokers and Non-Smokers Differs Significantly during Withdrawal
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Media type:
E-Article
Title:
Smoking and Promoter-Specific Deoxyribonucleic Acid Methylation of the Atrial Natriuretic Peptide Gene: Methylation of Smokers and Non-Smokers Differs Significantly during Withdrawal
Contributor:
Glahn, Alexander;
Rhein, Mathias;
Frieling, Helge;
Schuster, Rilana;
El Aissami, Alain;
Bleich, Stefan;
Hillemacher, Thomas;
Muschler, Marc
Published:
S. Karger AG, 2017
Published in:
European Addiction Research, 23 (2017) 6, Seite 306-311
Language:
English
DOI:
10.1159/000486279
ISSN:
1022-6877;
1421-9891
Origination:
Footnote:
Description:
<b><i>Background:</i></b> Atrial natriuretic peptide (ANP) is well known in psychiatric disorders to modulate hypothalamic-pituitary-adrenal axis activity. Disturbances of ANP have been described in early abstinent alcohol-dependent patients. This is the first longitudinal investigation on cytosine-phosphatidyl-guanine (CpG)-island promoter methylation of the <i>ANP</i> gene in the blood of tobacco-dependent patients. <b><i>Methods:</i></b> In a longitudinal approach, we investigated whether changes in ANP serum levels correlated to CpG methylation of the respective gene promoters on days 1, 7, and 14 of tobacco withdrawal. <b><i>Results</i></b> <b><i>and Conclusion:</i></b> Compared to non-smokers, promoter-related deoxyribonucleic acid methylation of the ANP promoter was significantly elevated on days 7 and 14 of withdrawal in tobacco-dependent patients. Baseline methylation status of the ANP promoter was not significantly different from controls, arguing for an impaired regulation during withdrawal.