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Lenti, Marco Vincenzo; Aronico, Nicola; Giuffrida, Paolo; Costa, Stefania; Costetti, Martina; Musacchio, Clarissa; Pastorelli, Luca; Mengoli, Caterina; Borrelli de Andreis, Federica; Cococcia, Sara; Tinelli, Carmine; Klersy, Catherine; Vecchi, Maurizio; Pilotto, Alberto; Di Sabatino, Antonio

Multidimensional Prognostic Index Predicts Clinical Outcome and Mortality in Hospitalised Older Patients with Diverticular Disease

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  • Media type: E-Article
  • Title: Multidimensional Prognostic Index Predicts Clinical Outcome and Mortality in Hospitalised Older Patients with Diverticular Disease
  • Contributor: Lenti, Marco Vincenzo; Aronico, Nicola; Giuffrida, Paolo; Costa, Stefania; Costetti, Martina; Musacchio, Clarissa; Pastorelli, Luca; Mengoli, Caterina; Borrelli de Andreis, Federica; Cococcia, Sara; Tinelli, Carmine; Klersy, Catherine; Vecchi, Maurizio; Pilotto, Alberto; Di Sabatino, Antonio
  • Published: S. Karger AG, 2022
  • Published in: Gerontology, 68 (2022) 1, Seite 44-52
  • Language: English
  • DOI: 10.1159/000515161
  • ISSN: 0304-324X; 1423-0003
  • Origination:
  • Footnote:
  • Description: <b><i>Introduction:</i></b> The Multidimensional Prognostic Index (MPI) is a validated tool for assessing mortality risk in hospitalised patients. We aimed to evaluate whether the MPI predicted mortality and the risk of developing diverticular disease (DD) complications in older patients. <b><i>Methods:</i></b> This is a multicentre study conducted in January 2016-March 2018. All patients with DD aged 65 years and older were included. Patients were stratified into three groups according to MPI groups (1, low risk; 2, moderate risk; 3, high risk). Risk of developing DD complications and mortality rate were assessed. Bivariate models were fitted. <b><i>Results:</i></b> One hundred hospitalised patients with DD (mean age 77.9 ± 10.6 years, 53 female patients) were included. Patients with higher MPI groups were more likely to develop DD complications. In particular, 12 (46.2%), 21 (52.5%), and 28 (82.4%) patients with complicated DD were distributed to the MPI 1, MPI 2, and MPI 3 groups (<i>p</i> = 0.0063), respectively. Two patients died in the MPI 1, 4 in the MPI 2, and 29 in the MPI 3 group, with mortality rates of 4.0 per 100 person-year (95% confidence interval [CI] 1.0–15.9), 5.6 (95% CI 2.1–15.0), and 89.2 (95% CI 62–130), respectively (log-rank test <i>p</i> < 0.001). In bivariate analysis, after adjustment for age >80 years, Charlson Comorbidity Index >4, DD complications, and the presence of thromboembolism, higher MPI group was independently associated with higher mortality. Those in the MPI 3 group experienced a greater risk of 1-year hospital readmission (<i>p</i> < 0.001). <b><i>Conclusion:</i></b> MPI predicted mortality in patients with DD and also correlated with the risk of developing DD complications. Studies focussing on possible pathophysiological mechanisms between DD complications and MPI are needed.