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Reiswich, Viktor; Schmidt, Carol E.; Lennartz, Maximilian; Höflmayer, Doris; Hube-Magg, Claudia; Weidemann, Sören; Fraune, Christoph; Büscheck, Franziska; Möller, Katharina; Bernreuther, Christian; Simon, Ronald; Clauditz, Till S.; Blessin, Niclas C.; Bady, Elena; Sauter, Guido; Uhlig, Ria; Steurer, Stefan; Minner, Sarah; Burandt, Eike; Dum, David; Marx, Andreas H.; Krech, Till; Lebok, Patrick; Hinsch, Andrea;

GATA3 Expression in Human Tumors: A Tissue Microarray Study on 16,557 Tumors

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  • Media type: E-Article
  • Title: GATA3 Expression in Human Tumors: A Tissue Microarray Study on 16,557 Tumors
  • Contributor: Reiswich, Viktor; Schmidt, Carol E.; Lennartz, Maximilian; Höflmayer, Doris; Hube-Magg, Claudia; Weidemann, Sören; Fraune, Christoph; Büscheck, Franziska; Möller, Katharina; Bernreuther, Christian; Simon, Ronald; Clauditz, Till S.; Blessin, Niclas C.; Bady, Elena; Sauter, Guido; Uhlig, Ria; Steurer, Stefan; Minner, Sarah; Burandt, Eike; Dum, David; Marx, Andreas H.; Krech, Till; Lebok, Patrick; Hinsch, Andrea;
  • Published: S. Karger AG, 2023
  • Published in: Pathobiology, 90 (2023) 4, Seite 219-232
  • Language: English
  • DOI: 10.1159/000527382
  • ISSN: 1015-2008; 1423-0291
  • Origination:
  • Footnote:
  • Description: Introduction: GATA3 is a transcription factor involved in epithelial cell differentiation. GATA3 immunostaining is used as a diagnostic marker for breast and urothelial cancer but can also occur in other neoplasms. Methods: To evaluate GATA3 in normal and tumor tissues, a tissue microarray containing 16,557 samples from 131 different tumor types and subtypes and 608 samples of 76 different normal tissue types was analyzed by immunohistochemistry. Results: GATA3 positivity was found in 69 different tumor types including 23 types (18%) with at least one strongly positive tumor. Highest positivity rates occurred in noninvasive papillary urothelial carcinoma (92–99%), lobular carcinoma (98%), carcinoma of no special type of the breast (92%), basal cell carcinoma of the skin (97%), invasive urothelial carcinoma (73%), T-cell lymphoma (23%), adenocarcinoma of the salivary gland (16%), squamous cell carcinoma of the skin (16%), and colorectal neuroendocrine carcinoma (12%). In breast cancer, low GATA3 staining was linked to high pT stage (p = 0.03), high BRE grade (p < 0.0001), HER2 overexpression (p = 0.0085), estrogen and progesterone receptor negativity (p < 0.0001 each), and reduced survival (p = 0.03). Conclusion: Our data demonstrate that GATA3 positivity can occur in various tumor entities. Low levels of GATA3 reflect cancer progression and poor patient prognosis in breast cancer.