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Media type:
E-Article
Title:
Frontline Therapy in Chronic Lymphocytic Leukemia
Contributor:
Arguello-Tomas, Miguel;
Albiol, Nil;
Moreno, Carol
Published:
S. Karger AG, 2024
Published in:
Acta Haematologica, 147 (2024) 1, Seite 47-59
Language:
English
DOI:
10.1159/000534730
ISSN:
0001-5792;
1421-9662
Origination:
Footnote:
Description:
<b><i>Background:</i></b> The treatment landscape of chronic lymphocytic leukemia (CLL) has tremendously evolved in the last decades, thanks to the introduction of more effective therapies. <b><i>Summary:</i></b> Frontline therapy for patients with CLL includes chemoimmunotherapy (CIT) and pathway inhibitors (PIs) (i.e., bruton tyrosine kinase inhibitors and BCL2 inhibitors); the latter has proved to be more effective than CIT mainly in patients with high-risk features (e.g., <i>TP53</i> aberrations and unmutated IGHV) with acceptable toxicity. Combinations of PIs are playing the protagonist role as frontline therapy for CLL. <b><i>Key Messages:</i></b> In this article, the management of treatment-naïve patients with CLL is discussed.