> Details

Parmentier, Corline E.J.; el Bakkali, Loubna; Verhagen, Elise A.; Steggerda, Sylke J.; Alderliesten, Thomas; Lequin, Maarten H.; van de Pol, Laura A.; Benders, Manon J.N.L.; van Bel, Frank; Koopman-Esseboom, Corine; de Haan, Timo R.; de Vries, Linda S.; Groenendaal, Floris

Brain MRI Injury Patterns across Gestational Age among Preterm Infants with Perinatal Asphyxia

Reference
management

Bookmarks

Remove from
bookmarks

Share this on Whatsapp

Close

Bookmarks



You can manage bookmarks using lists, please log in to your user account for this.
  • Media type: E-Article
  • Title: Brain MRI Injury Patterns across Gestational Age among Preterm Infants with Perinatal Asphyxia
  • Contributor: Parmentier, Corline E.J.; el Bakkali, Loubna; Verhagen, Elise A.; Steggerda, Sylke J.; Alderliesten, Thomas; Lequin, Maarten H.; van de Pol, Laura A.; Benders, Manon J.N.L.; van Bel, Frank; Koopman-Esseboom, Corine; de Haan, Timo R.; de Vries, Linda S.; Groenendaal, Floris
  • Published: S. Karger AG, 2024
  • Published in: Neonatology (2024), Seite 1-11
  • Language: English
  • DOI: 10.1159/000538986
  • ISSN: 1661-7800; 1661-7819
  • Origination:
  • Footnote:
  • Description: <b><i>Introduction:</i></b> Brain injury patterns of preterm infants with perinatal asphyxia (PA) are underreported. We aimed to explore brain magnetic resonance imaging (MRI) findings and associated neurodevelopmental outcomes in these newborns. <b><i>Methods:</i></b> Retrospective multicenter study included infants with gestational age (GA) 24.0–36.0 weeks and PA, defined as ≥2 of the following: (1) umbilical cord pH ≤7.0, (2) 5-min Apgar score ≤5, and (3) fetal distress or systemic effects of PA. Findings were compared between GA <28.0 (group 1), 28.0–31.9 (group 2), and 32.0–36.0 weeks (group 3). Early MRI (<36 weeks postmenstrual age or <10 postnatal days) was categorized according to predominant injury pattern, and MRI around term-equivalent age (TEA, 36.0–44.0 weeks and ≥10 postnatal days) using the Kidokoro score. Adverse outcomes included death, cerebral palsy, epilepsy, severe hearing/visual impairment, or neurodevelopment <-1 SD at 18–24 months corrected age. <b><i>Results:</i></b> One hundred nineteen infants with early MRI (<i>n</i> = 94) and/or MRI around TEA (<i>n</i> = 66) were included. Early MRI showed predominantly hemorrhagic injury in groups 1 (56%) and 2 (45%), and white matter (WM)/watershed injury in group 3 (43%). Around TEA, WM scores were highest in groups 2 and 3. Deep gray matter (DGM) (aOR 15.0, 95% CI: 3.8–58.9) and hemorrhagic injury on early MRI (aOR 2.5, 95% CI: 1.3–4.6) and Kidokoro WM (aOR 1.3, 95% CI: 1.0–1.6) and DGM sub-scores (aOR 4.8, 95% CI: 1.1–21.7) around TEA were associated with adverse neurodevelopmental outcomes. <b><i>Conclusion:</i></b> The brain injury patterns following PA in preterm infants differ across GA. Particularly DGM abnormalities are associated with adverse neurodevelopmental outcomes.