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Media type:
E-Article
Title:
Evaluation of New Approaches to Prophylactic and Therapeutic Vaccinations against Hepatitis B Viruses in the Woodchuck Model
Contributor:
Lu, Mengji;
Roggendorf, Michael
Published:
S. Karger AG, 2001
Published in:
Intervirology, 44 (2001) 2-3, Seite 124-131
Language:
English
DOI:
10.1159/000050039
ISSN:
0300-5526;
1423-0100
Origination:
Footnote:
Description:
The woodchuck model is most suitable for vaccine studies of prophylaxis and therapeutic treatment of hepatitis B virus infection. Recently, methodological advances allowed the examination of antigen-specific T cell responses in woodchucks during woodchuck hepatitis virus (WHV) infection and vaccinations. Similar to hepatitis B virus infection in humans, multispecific T-cell responses to WHV occur during acute self-limiting infection in woodchucks. Immunizations with WHV core antigen (WHcAg) or DNA vaccines expressing WHcAg demonstrated that priming of specific T-cell responses leads to the control of WHV infection. B-cell responses but no T-cell responses to WHV surface antigens (WHsAg) were induced in chronically WHV-infected woodchucks by the therapeutic immunizations with WHsAg. Breaking T-cell tolerance appears to be critical for immunotherapeutic approaches to chronic hepatitis B.