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von Bohlen und Halbach, Oliver; Schober, Andreas; Hertel, Richard; Unsicker, Klaus

MPTP Treatment Impairs Tyrosine Hydroxylase Immunopositive Fibers Not Only in the Striatum, but Also in the Amygdala

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  • Media type: E-Article
  • Title: MPTP Treatment Impairs Tyrosine Hydroxylase Immunopositive Fibers Not Only in the Striatum, but Also in the Amygdala
  • Contributor: von Bohlen und Halbach, Oliver; Schober, Andreas; Hertel, Richard; Unsicker, Klaus
  • Published: S. Karger AG, 2005
  • Published in: Neurodegenerative Diseases, 2 (2005) 1, Seite 44-48
  • Language: English
  • DOI: 10.1159/000086430
  • ISSN: 1660-2854; 1660-2862
  • Origination:
  • Footnote:
  • Description: Parkinson’s disease (PD) is characterized by a triad of symptoms (tremor, rigidity, and bradykinesia). Aside from this, emotional deficits are known to be associated with PD. A key structure of emotional processing is the amygdala. Emotional deficits seen in PD might be due to alterations in the catecholaminergic innervation of this limbic structure. We therefore examined whether 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) applied to C57/BL6 mice (an animal model of PD) affects the density of tyrosine hydroxylase (TH) immunoreactive fibers in the amygdala as it does in the striatum. MPTP treatment caused a prominent reduction in dopamine levels (about –70%) in the striatum (determined by high-performance liquid chromatography and electrochemical detection), accompanied by massive losses of TH-positive fibers in the striatum (–48.3%). Moreover, MPTP treatment caused prominent reductions of TH-positive fiber densities in the basolateral, lateral and central nucleus of the amygdala (about –20%). These results may provide the morphological basis for behavioral studies analyzing altered emotional responses in animal models of PD.