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Heide, Rogier; de Waard-van der Spek, Flora B.; den Hollander, Jan C.; Tank, Bhupendra; Oranje, Arnold P.

Efficacy of 25% Diluted Fluticasone Propionate 0.05% Cream as Wet-Wrap Treatment in Cutaneous Mastocytosis

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  • Media type: E-Article
  • Title: Efficacy of 25% Diluted Fluticasone Propionate 0.05% Cream as Wet-Wrap Treatment in Cutaneous Mastocytosis
  • Contributor: Heide, Rogier; de Waard-van der Spek, Flora B.; den Hollander, Jan C.; Tank, Bhupendra; Oranje, Arnold P.
  • Published: S. Karger AG, 2007
  • Published in: Dermatology, 214 (2007) 4, Seite 333-335
  • Language: English
  • DOI: 10.1159/000100885
  • ISSN: 1018-8665; 1421-9832
  • Origination:
  • Footnote:
  • Description: <i>Background:</i> Mastocytosis is a disorder that can be subdivided into two forms: cutaneous and systemic. Patients with cutaneous mastocytosis only may suffer from cosmetic problems. Topical steroid application has been shown to be effective in cases of limited skin lesions. <i>Methods:</i> A case-controlled pilot study was conducted during a 6-weeks treatment using diluted 25% fluticasone propionate 0.05% cream under wet-wrap occlusion in 5 adults and 6 children. Improvement was measured up to the 24th week after treatment using the SCORMA Index. <i>Results:</i> The results of this pilot study showed a partial but clear cosmetic improvement in 9 of the 11 patients. The mean SCORMA Index decreased after treatment from 38 to 26. <i>Conclusion:</i> 25% dilution of fluticasone propionate 0.05% cream under wet-wrap occlusion is an alternative treatment modality for alleviating the symptoms of cutaneous mastocytosis, but the improvement may be moderate and fall short of the patient’s expectations.