• Media type: E-Article
  • Title: Failure to Replicate Influence of GRIK4 and GNB3 Polymorphisms on Treatment Outcome in Major Depression
  • Contributor: Serretti, Alessandro; Chiesa, Alberto; Crisafulli, Concetta; Massat, Isabelle; Linotte, Sylvie; Calati, Raffaella; Kasper, Siegfried; Bailer, Ursula; Lecrubier, Yves; Fink, Martin; Antonijevic, Irina; Forray, Carlos; Snyder, Lenore; Bollen, Joseph; Zohar, Joseph; De Ronchi, Diana; Souery, Daniel; Mendlewicz, Julien
  • imprint: S. Karger AG, 2012
  • Published in: Neuropsychobiology
  • Language: English
  • DOI: 10.1159/000329553
  • ISSN: 0302-282X; 1423-0224
  • Keywords: Biological Psychiatry ; Psychiatry and Mental health ; Neuropsychology and Physiological Psychology
  • Origination:
  • Footnote:
  • Description: <jats:p>In the present study, we aimed to confirm the previous finding of an association between &lt;i&gt;GRIK4&lt;/i&gt; and &lt;i&gt;GNB3&lt;/i&gt; variants (rs195478 and rs5443) and remission and treatment resistance in major depression, using a multicenter sample of 223 patients. We did not find any supporting evidence for such associations. These conflicting data may result from difficulties in the replication of candidate gene association studies.</jats:p>