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Ristau, Tina; Keane, Pearse A.; Walsh, Alexander C.; Engin, Alicia; Mokwa, Nils; Kirchhof, Bernd; Sadda, SriniVas R.; Liakopoulos, Sandra

Relationship between Visual Acuity and Spectral Domain Optical Coherence Tomography Retinal Parameters in Neovascular Age-Related Macular Degeneration

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  • Media type: E-Article
  • Title: Relationship between Visual Acuity and Spectral Domain Optical Coherence Tomography Retinal Parameters in Neovascular Age-Related Macular Degeneration
  • Contributor: Ristau, Tina; Keane, Pearse A.; Walsh, Alexander C.; Engin, Alicia; Mokwa, Nils; Kirchhof, Bernd; Sadda, SriniVas R.; Liakopoulos, Sandra
  • imprint: S. Karger AG, 2014
  • Published in: Ophthalmologica
  • Language: English
  • DOI: 10.1159/000354551
  • ISSN: 0030-3755; 1423-0267
  • Keywords: Sensory Systems ; Ophthalmology ; General Medicine
  • Origination:
  • Footnote:
  • Description: <jats:p>&lt;b&gt;&lt;i&gt;Purpose:&lt;/i&gt;&lt;/b&gt; Relationship between spectral domain optical coherence tomography (SD-OCT) and visual acuity (VA) in neovascular age-related macular degeneration (NVAMD). &lt;b&gt;&lt;i&gt;Procedures:&lt;/i&gt;&lt;/b&gt; VA and SD-OCTs of 64 treatment-naive eyes with NVAMD were retrospectively collected at baseline and 1 year (n = 30). Retinal and subretinal spaces were manually analyzed. Volume and thickness measurements were correlated with VA. &lt;b&gt;&lt;i&gt;Results:&lt;/i&gt;&lt;/b&gt; At baseline, lower VA correlated with increased volume of subretinal hyperreflective material (R = 0.4, p &lt; 0.001) and with decreased volume of the photoreceptor layer (PRL, R = -0.4, p &lt; 0.01). At 1 year, lower VA correlated with decreased volume of the retina (R = -0.7, p &lt; 0.001), outer nuclear layer (R = -0.6, p &lt; 0.05) and PRL (R = -0.7, p &lt; 0.001). Decrease in VA after 1 year correlated with a decrease in PRL (R = 0.4, p &lt; 0.05). &lt;b&gt;&lt;i&gt;Conclusions:&lt;/i&gt;&lt;/b&gt; Quantitative analysis of SD-OCT revealed correlations between VA and retinal and subretinal morphological changes in NVAMD. &lt;b&gt;&lt;i&gt;Message:&lt;/i&gt;&lt;/b&gt; Atrophy of the outer retina is an important correlate for lower VA in NVAMD.</jats:p>