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Schaub, Christina; Greschus, Susanne; Seifert, Mirko; Waha, Andreas; Blasius, Elias; Rasch, Katja; Landwehr, Christiane; Mack, Frederic; Schäfer, Niklas; Stuplich, Moritz; Kebir, Sied; Vilz, Belinda; Scheffler, Björn; Boström, Jan; Simon, Matthias; Urbach, Horst; Glas, Martin; Herrlinger, Ulrich

FLAIR-Only Progression in Bevacizumab-Treated Relapsing Glioblastoma Does Not Predict Short Survival

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  • Media type: E-Article
  • Title: FLAIR-Only Progression in Bevacizumab-Treated Relapsing Glioblastoma Does Not Predict Short Survival
  • Contributor: Schaub, Christina; Greschus, Susanne; Seifert, Mirko; Waha, Andreas; Blasius, Elias; Rasch, Katja; Landwehr, Christiane; Mack, Frederic; Schäfer, Niklas; Stuplich, Moritz; Kebir, Sied; Vilz, Belinda; Scheffler, Björn; Boström, Jan; Simon, Matthias; Urbach, Horst; Glas, Martin; Herrlinger, Ulrich
  • imprint: S. Karger AG, 2013
  • Published in: Oncology
  • Language: English
  • DOI: 10.1159/000354692
  • ISSN: 0030-2414; 1423-0232
  • Keywords: Cancer Research ; Oncology ; General Medicine
  • Origination:
  • Footnote:
  • Description: <jats:p>&lt;b&gt;&lt;i&gt;Objectives:&lt;/i&gt;&lt;/b&gt; In this study, we analyzed the prognostic value of different MRI progression patterns for survival in patients with recurrent malignant glioma treated with the vascular endothelial growth factor antibody bevacizumab. &lt;b&gt;&lt;i&gt;Patients and Methods:&lt;/i&gt;&lt;/b&gt; Twenty-six adult patients with recurrent malignant glioma treated with bevacizumab or bevacizumab/irinotecan were retrospectively analyzed for the development of contrast-enhanced (T1-weighted MRI) and T2/FLAIR lesions. According to the progression pattern, patients were divided into 3 subgroups: (1) patients with primarily progressive contrast-enhanced lesions in the first MRI after initiation of therapy (‘primary PD group'); (2) patients with stable or regressive enhanced lesions but progressive FLAIR lesions (‘FLAIR-only PD group'), and (3) patients with stable or regressive contrast-enhanced T1 and FLAIR lesions (‘no PD group'). &lt;b&gt;&lt;i&gt;Results:&lt;/i&gt;&lt;/b&gt; Overall survival (OS) in the 6 patients in the FLAIR-only PD group was not significantly different from the 11 patients in the no PD group (median 311 vs. 254 days, respectively). In contrast, survival in the FLAIR-only PD group was significantly better (p = 0.025) than in the primary PD group. &lt;b&gt;&lt;i&gt;Conclusion:&lt;/i&gt;&lt;/b&gt; FLAIR-only progression is not an independent prognostic factor negatively influencing OS in recurrent glioblastoma treated with bevacizumab and should not lead to discontinuation of bevacizumab therapy.</jats:p>