> Details

Humpe, Andreas; Buwitt-Beckmann, Ute; Schub, Natalie; Gramatzki, Martin; Günther, Andreas

Successful Mobilization, Intra-Apheresis Recruitment, and Harvest of Hematopoietic Progenitor Cells by Addition of Plerixafor and Subsequent Large-Volume Leukapheresis

Reference
management

Bookmarks

Remove from
bookmarks

Share this on Whatsapp

Close

Bookmarks



You can manage bookmarks using lists, please log in to your user account for this.
  • Media type: E-Article
  • Title: Successful Mobilization, Intra-Apheresis Recruitment, and Harvest of Hematopoietic Progenitor Cells by Addition of Plerixafor and Subsequent Large-Volume Leukapheresis
  • Contributor: Humpe, Andreas; Buwitt-Beckmann, Ute; Schub, Natalie; Gramatzki, Martin; Günther, Andreas
  • Published: S. Karger AG, 2013
  • Published in: Transfusion Medicine and Hemotherapy, 40 (2013) 4, Seite 251-257
  • Language: English
  • DOI: 10.1159/000354377
  • ISSN: 1660-3796; 1660-3818
  • Keywords: Hematology ; Immunology and Allergy
  • Origination:
  • Footnote:
  • Description: <jats:p>&lt;b&gt;&lt;i&gt;Background: &lt;/i&gt;&lt;/b&gt;In patients failing successful conventional mobilization of hematopoietic progenitor cells (HPC) plerixafor (Mozobil®) seems to be an alternative. We report a series of 14 patients with multiple myeloma or NHL successfully mobilized and harvested by plerixafor together with large-volume leukaphereses (LVL). &lt;b&gt;&lt;i&gt;Methods: &lt;/i&gt;&lt;/b&gt;In a first series (GI), 5 patients were mobilized with G-CSF and plerixafor. In the second series (GII), 9 patients were mobilized by chemotherapy, G-CSF, and plerixafor. &lt;b&gt;&lt;i&gt;Results: &lt;/i&gt;&lt;/b&gt;In GI and GII, addition of plerixafor led to a significant (p &lt; 0.01) increase of leukocytes and CD34+ cells in peripheral blood (PB). In GII, the median number of CD34+ cells in PB before and after addition of plerixafor was significantly (p = 0.019) higher compared to GI (9 vs. 5 and 50 vs. 24 cells/µl, respectively). In GI and GII, a median number of three or one aphereses was performed. In GII, the median yield (6.7 × 10&lt;sup&gt;6&lt;/sup&gt; CD34+ cells/kg) of the first apheresis and the median intra-apheresis recruitment of CD34+ cells were significantly (p &lt; 0.05) higher compared to GI (2.94 × 10&lt;sup&gt;6&lt;/sup&gt; CD34+ cells/kg). All patients transplanted, 5 in GI and 8 in GII, exhibited successful engraftment. &lt;b&gt;&lt;i&gt;Conclusions: &lt;/i&gt;&lt;/b&gt;Plerixafor and G-CSF mobilization or the addition of plerixafor during non-optimal chemotherapy and G-CSF mobilization together with LVL enabled, independent of leukocyte count and even without detectable CD34+ cells before addition of plerixafor, sufficient harvest of HPC numbers for transplantation. Addition of plerixafor during chemotherapy and G-CSF mobilization led to an increased intra-apheresis recruitment and a significantly higher yield of CD34+ cells compared to plerixafor and G-CSF steady-state mobilized patients.</jats:p>