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Barbarroja-Escudero, José; Prieto-Martin, Alfredo; Monserrat-Sanz, Jorge; Reyes-Martin, Eduardo; Diaz-Martin, David; Antolin-Amerigo, Dario; Rodriguez-Rodriguez, Mercedes; Canseco-Gonzalez, Felipe; Kremer, Leonor; Martinez-A, Carlos; Alvarez-Mon, Melchor

Abnormal Chemokine Receptor Profile on Circulating T Lymphocytes from Nonallergic Asthma Patients

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  • Media type: E-Article
  • Title: Abnormal Chemokine Receptor Profile on Circulating T Lymphocytes from Nonallergic Asthma Patients
  • Contributor: Barbarroja-Escudero, José; Prieto-Martin, Alfredo; Monserrat-Sanz, Jorge; Reyes-Martin, Eduardo; Diaz-Martin, David; Antolin-Amerigo, Dario; Rodriguez-Rodriguez, Mercedes; Canseco-Gonzalez, Felipe; Kremer, Leonor; Martinez-A, Carlos; Alvarez-Mon, Melchor
  • Published: S. Karger AG, 2014
  • Published in: International Archives of Allergy and Immunology, 164 (2014) 3, Seite 228-236
  • Language: English
  • DOI: 10.1159/000365627
  • ISSN: 1018-2438; 1423-0097
  • Origination:
  • Footnote:
  • Description: <b><i>Background:</i></b> T lymphocytes are involved in the pathogenesis of nonallergic asthma. The objective of this study was to characterize the subset distribution and pattern of chemokine receptor expression in circulating T lymphocyte subsets from nonallergic asthma patients. <b><i>Methods:</i></b> Forty stable nonallergic asthma patients and 16 sex- and age-matched healthy donors were studied. Twelve patients did not receive inhaled steroids (untreated patients), 16 received 50-500 μg b.i.d. of inhaled fluticasone propionate (FP) (standard-dose patients), and 12 received over 500 μg b.i.d. of inhaled FP (high-dose patients) for at least 12 months prior to the beginning of this study and were clinically well controlled. Flow cytometry was performed using a panel of monoclonal antibodies (4 colors). <b><i>Results:</i></b> Nonallergic asthma patients treated with high doses of inhaled FP showed a significant reduction in the percentages of CD3+ T lymphocytes compared to healthy controls. Untreated patients showed a significant increase in CCR6 expression in CD8+CD25+ and CD8+CD25+bright T cells compared to healthy controls. The results were similar for CXCR3 and CCR5 expression. In patients treated with standard doses of FP, CCR5 expression was significantly increased in CD3+ T lymphocytes relative to healthy controls. <b><i>Conclusions:</i></b> The different groups of clinically stable nonallergic asthmatic patients showed distinct patterns of alterations in subset distribution as well as CCR6, CXCR3, and CCR5 expression on circulating T lymphocytes.