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Wu, Meng; Ries, Jean-Jacques; Proietti, Elena; Vogt, Deborah; Hahn, Sinuhe; Hoesli, Irene

Development of Late-Onset Preeclampsia in Association with Road Densities as a Proxy for Traffic-Related Air Pollution

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  • Media type: E-Article
  • Title: Development of Late-Onset Preeclampsia in Association with Road Densities as a Proxy for Traffic-Related Air Pollution
  • Contributor: Wu, Meng; Ries, Jean-Jacques; Proietti, Elena; Vogt, Deborah; Hahn, Sinuhe; Hoesli, Irene
  • imprint: S. Karger AG, 2016
  • Published in: Fetal Diagnosis and Therapy
  • Language: English
  • DOI: 10.1159/000381802
  • ISSN: 1015-3837; 1421-9964
  • Keywords: Obstetrics and Gynecology ; Radiology, Nuclear Medicine and imaging ; Embryology ; General Medicine ; Pediatrics, Perinatology and Child Health
  • Origination:
  • Footnote:
  • Description: <jats:p>&lt;b&gt;&lt;i&gt;Introduction:&lt;/i&gt;&lt;/b&gt; Previous epidemiological studies indicate an association between maternal exposure to air pollution and an increased risk of hypertensive disorders in pregnancy. We analyzed the association between the occurrence of mild/severe and early-/late-onset preeclampsia (PE) and traffic-related air pollution (TRAP). &lt;b&gt;&lt;i&gt;Materials and Methods:&lt;/i&gt;&lt;/b&gt; Based on retrospective data, 50 pregnant women with PE were selected and matched with a control group of healthy pregnant women according to their age, parity, and number of fetuses. The total length of major roads around the women's home within a radius of 100, 200, 300, and 500 m and the distances from the domicile to the nearest ‘first class' main road and freeway were used as a proxy indicator of TRAP. We compared a PE subgroup and control group in terms of their exposure to TRAP. &lt;b&gt;&lt;i&gt;Results:&lt;/i&gt;&lt;/b&gt; Late-onset PE cases showed a significantly higher occurrence with density of major roads within a radius of 100-300 m compared to early onset cases (p = 0.006; 0.02; 0.04). In addition, a significantly shorter distance to the nearest ‘first class' main road was observed in late-onset PE cases (p = 0.0078). &lt;b&gt;&lt;i&gt;Conclusions:&lt;/i&gt;&lt;/b&gt; Exposure to TRAP during pregnancy was associated with an increased risk for the development of late-onset PE.</jats:p>