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Media type:
E-Article
Title:
Accuracy of In Vivo Carotid B-Mode Ultrasound Compared With Pathological Analysis : Intima-Media Thickening, Lumen Diameter, and Cross-Sectional Area
:
Intima-Media Thickening, Lumen Diameter, and Cross-Sectional Area
Published in:
Stroke, 32 (2001) 7, Seite 1520-1524
Language:
English
DOI:
10.1161/01.str.32.7.1520
ISSN:
0039-2499;
1524-4628
Origination:
Footnote:
Description:
<jats:p>
<jats:italic>Background and Purpose</jats:italic>
—This study aimed to determine the correlation of in vivo ultrasound measurements of intima-media thickening (IMT), lumen diameter, and cross-sectional area of the common carotid artery (CCA) with corresponding measurements obtained by gross pathology and histology.
</jats:p>
<jats:p>
<jats:italic>Methods</jats:italic>
—Sixty-six moribund neurological patients (mean age 71 years) underwent B-mode ultrasound of the CCA a few days before death. During autopsy, carotid specimens were removed in toto. Carotid arteries were ligated and cannulated for injection of a hydrophilic embedding material under standardized conditions. The carotid bifurcation was frozen and cut manually in 3-mm cross slices. Digital image analysis was carried out to determine the diameter and the cross-sectional area of the frozen slices of the CCA. IMT was assessed by light microscope. Ultrasonic and planimetric data were compared.
</jats:p>
<jats:p>
<jats:italic>Results</jats:italic>
—Mean measurements of lumen diameter and cross-sectional area were 7.13±1.27 mm and 0.496±0.167 cm
<jats:sup>2</jats:sup>
, respectively, by ultrasound, and 7.81±1.45 mm and 0.516±0.194 cm
<jats:sup>2</jats:sup>
, respectively, by planimetric analysis of the unfixed redistended carotid arteries (
<jats:italic>R</jats:italic>
<jats:sup>2</jats:sup>
=0.389 and 0.497). The mean IMT was 1.005±0.267 mm by ultrasound and 0.67±0.141 mm histologically, resulting in a mean difference of −31%.
</jats:p>
<jats:p>
<jats:italic>Conclusions</jats:italic>
—Transcutaneous B-mode ultrasound provides a reliable approach for in vivo measurements of the cross-sectional area and, less exactly, of the lumen diameter of the CCA. Compared with histological results, in vivo ultrasound measurements of the IMT are systematically larger.
</jats:p>