> Details

Saku, Keita; Kishi, Takuya; Nishizaki, Akiko; Fujii, Kana; Akashi, Takuya; Takehara, Takako; Oga, Yasuhiro; Kakino, Takamori; Ikeda, Masataka; Ide, Tomomi; Sunagawa, Kenji

Abstract 17082: Carotid Body Denervation Improves Autonomic Balance and Prevents the Worsening of Heart Failure in Rats After Large Myocardial Infarction

Reference
management

Bookmarks

Remove from
bookmarks

Share this on Whatsapp

Close

Bookmarks



You can manage bookmarks using lists, please log in to your user account for this.
  • Media type: E-Article
  • Title: Abstract 17082: Carotid Body Denervation Improves Autonomic Balance and Prevents the Worsening of Heart Failure in Rats After Large Myocardial Infarction
  • Contributor: Saku, Keita; Kishi, Takuya; Nishizaki, Akiko; Fujii, Kana; Akashi, Takuya; Takehara, Takako; Oga, Yasuhiro; Kakino, Takamori; Ikeda, Masataka; Ide, Tomomi; Sunagawa, Kenji
  • imprint: Ovid Technologies (Wolters Kluwer Health), 2014
  • Published in: Circulation
  • Language: English
  • DOI: 10.1161/circ.130.suppl_2.17082
  • ISSN: 0009-7322; 1524-4539
  • Keywords: Physiology (medical) ; Cardiology and Cardiovascular Medicine
  • Origination:
  • Footnote:
  • Description: <jats:p> <jats:bold>Introduction:</jats:bold> Carotid body denervation (CBD) abolishes the carotid body hypersensitivity induced sympathoexcitatory hypertension. Since the carotid body hypersensitivity is a salient feature and predicts poor outcome of chronic heart failure (CHF), we hypothesized that CBD restores normal autonomic balance, thus improves CHF in rats after large myocardial infarction (MI). </jats:p> <jats:p> <jats:bold>Methods:</jats:bold> We created MI in 8 weeks Sprague-Dawley rats. Surviving rats at 2 weeks after MI were randomized into CBD (n=11) and sham-operated (Sham; n=13) groups. We removed the tissues around the carotid bifurcation and established CBD. In some rats (Sham; n=5, CBD; n=5), we telemetrically recorded heart rate (HR). One month after CBD, we compared physiological, histological and immunochemical findings between CBD and Sham. </jats:p> <jats:p> <jats:bold>Results:</jats:bold> CBD significantly reduced HR (337±15 vs. 364±12 bpm, p&lt;0.05). CBD markedly increased the power spectral density of HR in the high frequency range (81.0±9.5 vs. 29.0±8.2 n.u., p&lt;0.05) and decreased that of the low frequency/high frequency ratio (0.6±0.2 vs. 1.8±0.5, p&lt;0.05) indicating the restoration of autonomic balance. CBD significantly reduced biventricular weight (3.1±0.3 vs. 3.7±0.3 g/kg, p&lt;0.05) and left ventricle (LV) end-diastolic pressure (22±5 vs. 33±5 mmHg, p&lt;0.01) and increased maximum LV dp/dt (5118±809 vs. 4217±472 mmHg/sec, p&lt;0.05). CBD reduced lung weight (a marker of pulmonary edema) (6.8±2.0 vs. 12.4±1.5 g/kg, p&lt;001). Furthermore, CBD reduced plasma brain natriuretic peptide (70±43 vs. 166±71 pg/ml, p&lt;0.01) and plasma norepinephrine as an index of sympathetic drive (384±202 vs. 1048±997 pg/ml, p&lt;0.05). CBD significantly reduced the number of inflammatory macrophages (345±45 vs. 474±73 counts/mm2, p&lt;0.05) in the LV and the plasma concentration of interleukin-1β (14.3±4.7 vs. 24.5±11.8 pg/ml, p&lt;0.05) indicating that CBD also suppressed the inflammatory response in CHF. </jats:p> <jats:p> <jats:bold>Conclusions:</jats:bold> CBD restores normal autonomic balance and prevents the worsening of heart failure in rats after large myocardial infarction. CBD may serve as a novel neuro-modulatory therapy for CHF patients. </jats:p>
  • Access State: Open Access