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Mangner, Norman; Stachel, Georg; Woitek, Felix; Haussig, Stephan; Schlotter, Florian; Höllriegel, Robert; Adam, Jennifer; Lindner, Anna; Mohr, Friedrich W.; Schuler, Gerhard; Kiefer, Philipp; Leontyev, Sergey; Borger, Michael A.; Thiele, Holger; Holzhey, David; Linke, Axel

Predictors of Mortality and Symptomatic Outcome of Patients With Low‐Flow Severe Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement

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  • Media type: E-Article
  • Title: Predictors of Mortality and Symptomatic Outcome of Patients With Low‐Flow Severe Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement
  • Contributor: Mangner, Norman; Stachel, Georg; Woitek, Felix; Haussig, Stephan; Schlotter, Florian; Höllriegel, Robert; Adam, Jennifer; Lindner, Anna; Mohr, Friedrich W.; Schuler, Gerhard; Kiefer, Philipp; Leontyev, Sergey; Borger, Michael A.; Thiele, Holger; Holzhey, David; Linke, Axel
  • imprint: Ovid Technologies (Wolters Kluwer Health), 2018
  • Published in: Journal of the American Heart Association
  • Language: English
  • DOI: 10.1161/jaha.117.007977
  • ISSN: 2047-9980
  • Keywords: Cardiology and Cardiovascular Medicine
  • Origination:
  • Footnote:
  • Description: <jats:sec xml:lang="en"> <jats:title>Background</jats:title> <jats:p xml:lang="en"> Impaired left ventricular (LV) ejection fraction is a common finding in patients with aortic stenosis and serves as a predictor of morbidity and mortality after transcatheter aortic valve replacement. However, conflicting data on the most accurate measure for <jats:styled-content style="fixed-case">LV</jats:styled-content> function exist. We wanted to examine the impact of LV ejection fraction, mean pressure gradient, and stroke volume index on the outcome of patients treated by transcatheter aortic valve replacement. </jats:p> </jats:sec> <jats:sec xml:lang="en"> <jats:title>Methods and Results</jats:title> <jats:p xml:lang="en"> Patients treated by transcatheter aortic valve replacement were primarily separated into normal flow ( <jats:styled-content style="fixed-case">NF</jats:styled-content> ; stroke volume index &gt;35 mL/m <jats:sup>2</jats:sup> ) and low flow ( <jats:styled-content style="fixed-case">LF</jats:styled-content> ; stroke volume index ≤35 mL/m <jats:sup>2</jats:sup> ). Afterwards, patients were divided into 5 groups: “NF–high gradient,” “NF–low gradient” ( <jats:styled-content style="fixed-case">NF</jats:styled-content> ‐ <jats:styled-content style="fixed-case">LG</jats:styled-content> ), “LF–high gradient,” “paradoxical LF‐LG,” and “classic LF‐LG.” The 3‐year mortality was the primary end point. Of 1600 patients, 789 (49.3%) were diagnosed as having <jats:styled-content style="fixed-case">LF</jats:styled-content> , which was characterized by a higher 30‐day ( <jats:italic>P</jats:italic> =0.041) and 3‐year ( <jats:italic>P</jats:italic> &lt;0.001) mortality. <jats:styled-content style="fixed-case">LF</jats:styled-content> was an independent predictor of all‐cause (hazard ratio, 1.29; 95% confidence interval, 1.03–1.62; <jats:italic>P</jats:italic> =0.03) and cardiovascular (hazard ratio, 1.37; 95% confidence interval, 1.06–1.77; <jats:italic>P</jats:italic> =0.016) mortality. Neither mean pressure gradient nor LV ejection fraction was an independent predictor of mortality. Patients with paradoxical LF‐LG (35.0%), classic LF‐LG (35.1%) and <jats:styled-content style="fixed-case">LF</jats:styled-content> –high gradient (38.1%) had higher all‐cause mortality at 3 years compared with <jats:styled-content style="fixed-case">NF</jats:styled-content> –high gradient (24.8%) and <jats:styled-content style="fixed-case">NF</jats:styled-content> ‐ <jats:styled-content style="fixed-case">LG</jats:styled-content> (27.9%) ( <jats:italic>P</jats:italic> =0.001). However, surviving patients showed a similar improvement in symptoms regardless of aortic stenosis entity. </jats:p> </jats:sec> <jats:sec xml:lang="en"> <jats:title>Conclusions</jats:title> <jats:p xml:lang="en"> <jats:styled-content style="fixed-case">LF</jats:styled-content> is a common finding within the aortic stenosis population and, in contrast to LV ejection fraction or mean pressure gradient, an independent predictor of all‐cause and cardiovascular mortality. Despite increased long‐term mortality, high procedural success and excellent functional improvement support transcatheter aortic valve replacement in patients with <jats:styled-content style="fixed-case">LF</jats:styled-content> severe aortic stenosis. </jats:p> </jats:sec>
  • Access State: Open Access