Clinical Features and Outcomes of Patients With Malignancy and Takotsubo Syndrome: Observations From the International Takotsubo Registry

Media type: E-Article
Title: Clinical Features and Outcomes of Patients With Malignancy and Takotsubo Syndrome: Observations From the International Takotsubo Registry
Contributor: Cammann, Victoria L.; Sarcon, Annahita; Ding, Katharina J.; Seifert, Burkhardt; Kato, Ken; Di Vece, Davide; Szawan, Konrad A.; Gili, Sebastiano; Jurisic, Stjepan; Bacchi, Beatrice; Micek, Jozef; Frangieh, Antonio H.; Napp, L. Christian; Jaguszewski, Milosz; Bossone, Eduardo; Citro, Rodolfo; D'Ascenzo, Fabrizio; Franke, Jennifer; Noutsias, Michel; Knorr, Maike; Heiner, Susanne; Burgdorf, Christof; Koenig, Wolfgang; Thiele, Holger; [...]
imprint: Ovid Technologies (Wolters Kluwer Health), 2019
Published in: Journal of the American Heart Association
Language: English
DOI: 10.1161/jaha.118.010881
ISSN: 2047-9980
Keywords: Cardiology and Cardiovascular Medicine
Origination:
Footnote:
Description: <jats:sec xml:lang="en"> <jats:title>Background</jats:title> <jats:p xml:lang="en"> Clinical characteristics and outcomes of takotsubo syndrome ( <jats:styled-content style="fixed-case">TTS</jats:styled-content> ) patients with malignancy have not been fully elucidated. This study sought to explore differences in clinical characteristics and to investigate short‐ and long‐term outcomes in <jats:styled-content style="fixed-case">TTS</jats:styled-content> patients with or without malignancy. </jats:p> </jats:sec> <jats:sec xml:lang="en"> <jats:title>Methods and Results</jats:title> <jats:p xml:lang="en"> <jats:styled-content style="fixed-case">TTS</jats:styled-content> patients were enrolled from the International Takotsubo Registry. The <jats:styled-content style="fixed-case">TTS</jats:styled-content> cohort was divided into patients with and without malignancy to investigate differences in clinical characteristics and to assess short‐ and long‐term mortality. A subanalysis was performed comparing long‐term mortality between a subset of <jats:styled-content style="fixed-case">TTS</jats:styled-content> patients with or without malignancy and acute coronary syndrome (ACS) patients with or without malignancy. Malignancy was observed in 16.6% of 1604 <jats:styled-content style="fixed-case">TTS</jats:styled-content> patients. Patients with malignancy were older and more likely to have physical triggers, but less likely to have emotional triggers compared with those without malignancy. Long‐term mortality was higher in patients with malignancy ( <jats:italic>P</jats:italic> <0.001), while short‐term outcome was comparable ( <jats:italic>P</jats:italic> =0.17). In a subanalysis, long‐term mortality was comparable between <jats:styled-content style="fixed-case">TTS</jats:styled-content> patients with malignancies and ACS patients with malignancies ( <jats:italic>P</jats:italic> =0.13). Malignancy emerged as an independent predictor of long‐term mortality. </jats:p> </jats:sec> <jats:sec xml:lang="en"> <jats:title>Conclusions</jats:title> <jats:p xml:lang="en"> A substantial number of <jats:styled-content style="fixed-case">TTS</jats:styled-content> patients show an association with malignancy. History of malignancy might increase the risk for <jats:styled-content style="fixed-case">TTS</jats:styled-content> , and therefore, appropriate screening for malignancy should be considered in these patients. </jats:p> </jats:sec> <jats:sec xml:lang="en"> <jats:title>Clinical Trial Registration</jats:title> <jats:p xml:lang="en"> <jats:styled-content style="fixed-case">URL</jats:styled-content> : <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://www.clinicaltrial.gov">http://www.clinicaltrial.gov</jats:ext-link> . Unique identifier: <jats:styled-content style="fixed-case">NCT</jats:styled-content> 01947621. </jats:p> </jats:sec>
Access State: Open Access

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