CRP Gene Haplotypes, Serum CRP, and Cerebral Small-Vessel Disease : The Rotterdam Scan Study and the MEMO Study
: The Rotterdam Scan Study and the MEMO Study
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Media type:
E-Article
Title:
CRP Gene Haplotypes, Serum CRP, and Cerebral Small-Vessel Disease : The Rotterdam Scan Study and the MEMO Study
:
The Rotterdam Scan Study and the MEMO Study
Description:
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<jats:bold>
<jats:italic>Background and Purpose—</jats:italic>
</jats:bold>
It remains unclear whether C-reactive protein (CRP) is a serum marker for atherothrombotic disease or a causal factor in the pathogenesis of atherosclerosis. We explored the association between
<jats:italic>CRP</jats:italic>
gene variations and cerebral small-vessel disease (SVD) in the Rotterdam Scan Study (N=1035) and the MEMO Study (N=268).
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<jats:p>
<jats:bold>
<jats:italic>Methods—</jats:italic>
</jats:bold>
Common haplotypes within the
<jats:italic>CRP</jats:italic>
gene were determined by genotype-tagging single-nucleotide polymorphisms. Then their relation with periventricular and subcortical white matter lesions and the prevalence of lacunar brain infarcts was explored by regression analyses.
</jats:p>
<jats:p>
<jats:bold>
<jats:italic>Results—</jats:italic>
</jats:bold>
There was no association between
<jats:italic>CRP</jats:italic>
haplotypes and measures of cerebral SVD in either study. There was no effect modification of the association between serum CRP levels and measures of SVD by
<jats:italic>CRP</jats:italic>
haplotypes.
</jats:p>
<jats:p>
<jats:bold>
<jats:italic>Conclusions—</jats:italic>
</jats:bold>
Our observations suggest that CRP is not causally involved in the pathogenesis of SVD.
</jats:p>