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Voucharas, Christos; Tagarakis, Georgios; Lazou, Antigoni; Triposkiadis, Filippos; Tsilimingas, Nikolaos

Experimental Cardiac Hypertrophy Induced by Oral Administration of Mineralocorticoid and Saline in Rats

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  • Media type: E-Article
  • Title: Experimental Cardiac Hypertrophy Induced by Oral Administration of Mineralocorticoid and Saline in Rats
  • Contributor: Voucharas, Christos; Tagarakis, Georgios; Lazou, Antigoni; Triposkiadis, Filippos; Tsilimingas, Nikolaos
  • Published: SAGE Publications, 2012
  • Published in: Angiology, 63 (2012) 6, Seite 416-419
  • Language: English
  • DOI: 10.1177/0003319711423529
  • ISSN: 0003-3197; 1940-1574
  • Keywords: Cardiology and Cardiovascular Medicine
  • Origination:
  • Footnote:
  • Description: We suggest a new, easily applicable way of myocardial hypertrophy induction in rats. Forty randomized age-matched male Wistar rats were divided into 2 groups of 20 each: a control group and an orally administered fludrocortisone/salt group. Myocardial hypertrophy was estimated by measuring body weight, heart-weight-to-body-weight ratio and ventricular free wall thickness. Moderate myocardial hypertrophy without heart failure was established in fludrocortisone/salt group in 4 weeks. Our method is effective and low cost, and it provides a model of hypertrophic heart.