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Media type:
E-Article
Title:
Aortic Connective Tissue in Atherosclerotic Aorta— A Biochemical Study
Contributor:
Andreotti, Lupo;
Bussotti, Alessandro;
Cammelli, Daniele;
di Giovine, Francesco;
Sterrantino, Gaetana;
Varcasia, Giuseppe;
Arcangeli, Paolo
Published:
SAGE Publications, 1986
Published in:
Angiology, 37 (1986) 10, Seite 735-743
Language:
English
DOI:
10.1177/000331978603701007
ISSN:
0003-3197;
1940-1574
Origination:
Footnote:
Description:
Biochemical analysis of the extracellular matrix of human aortas was per formed on samples of ascending and descending aortas affected by atherosclero sis in comparison with a control group of nonatherosclerotic aortas. Ulcerated or heavily calcified atheromas were excised and excluded from the analysis in order to differentiate biochemical alterations leading to the forma tion of atheromas from those due to complications of already formed athero mas. Our results show that the development of atheromas brings about an exten sive destruction of elastic fibers and muscular cells, and their place is occupied by other components of the extracellular matrix, most notably, collagen, non uronic sugars, water, and lipids, which were found significantly increased.