Holmes, Ann R.;
Chong, Kenneth;
Rodrigues, Ely;
Cannon, Richard D.;
Carpenter, Elizabeth;
Ruske, Dean R.;
Dawes, Patrick J. D.
Yeast Colonization of Voice Prostheses: Pilot Study Investigating Effect of a Bovine Milk Product Containing Anti—Candida Albicans Immunoglobulin A Antibodies on Yeast Colonization and Valve Leakage
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Media type:
E-Article
Title:
Yeast Colonization of Voice Prostheses: Pilot Study Investigating Effect of a Bovine Milk Product Containing Anti—Candida Albicans Immunoglobulin A Antibodies on Yeast Colonization and Valve Leakage
Contributor:
Holmes, Ann R.;
Chong, Kenneth;
Rodrigues, Ely;
Cannon, Richard D.;
Carpenter, Elizabeth;
Ruske, Dean R.;
Dawes, Patrick J. D.
imprint:
SAGE Publications, 2012
Published in:Annals of Otology, Rhinology & Laryngology
Description:
<jats:sec><jats:title>Objectives:</jats:title><jats:p> Our goals were to determine whether a bovine milk product containing anti– Candida albicans immunoglobulin A antibodies (“immune milk”) could reduce the adherence of C albicans to voice prosthesis silicone in vitro, and whether administration of the milk could reduce C albicans colonization and voice prosthesis damage in vivo. </jats:p></jats:sec><jats:sec><jats:title>Methods:</jats:title><jats:p> An in vitro assay of C albicans attachment to silicone was developed with radiolabeled C albicans. A pilot crossover in vivo trial, over 3 periods of 3 months, was also undertaken for 4 patients with voice prostheses, comparing daily administrations of immune milk and a control milk product. The prosthesis valves were replaced at each change-over and were assessed for wet weight of removable biofilm, yeast numbers in removable biofilm, valve leakage, and valve damage. </jats:p></jats:sec><jats:sec><jats:title>Results:</jats:title><jats:p> Immune milk inhibited C albicans adherence to silicone in vitro. However, in a small clinical pilot study, this effect was not replicated. </jats:p></jats:sec><jats:sec><jats:title>Conclusions:</jats:title><jats:p> There is scope to further investigate the topical use of immune milk for management of voice prosthesis biofilms. </jats:p></jats:sec>