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Media type:
E-Article
Title:
A new automated system for the preparation of sclerosant foam: A study of the physical characteristics produced and the device settings required
Contributor:
Roche, Enric;
Pons, Ramon;
Roche, Oriol;
Puig, Antoni
imprint:
SAGE Publications, 2020
Published in:
Phlebology: The Journal of Venous Disease, 35 (2020) 9, Seite 724-733
Description:
<jats:sec><jats:title>Objectives</jats:title><jats:p> To determine the quality of sclerosant foam produced with an automated preparation system with multiple combinations of sclerosing agents, gases, and device settings. </jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p> Single-use mixing capsules filled with air or O<jats:sub>2</jats:sub>/CO<jats:sub>2</jats:sub> and polidocanol (0.25, 1, or 3%) or sodium tetradecyl sulfate (0.2 or 1%) were coupled to a customized magnetic stirrer. Stirring speed and time were adjusted between 1500 and 4000 r/min and 30 and 60 s, respectively, and characteristics of the foam produced were measured: half-life, bubble diameter, and gas-to-liquid ratio. </jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p> With optimized device settings, the following foam characteristics were obtained: half-life range, 1.4 ± 0.9 to 5.2 ± 0.6 min; bubble diameter, 84 ± 14 to 119 ± 6 µm; and gas-to-liquid ratio, 5:1–7:1. Sodium tetradecyl sulfate foam was quicker to form than polidocanol but faster to degrade. Foams with low sclerosant concentrations and O<jats:sub>2</jats:sub>/CO<jats:sub>2</jats:sub> required higher speed and longer time. </jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p> Suitable foam characteristics could be obtained with all combinations of sclerosing agent, concentration, and gas. </jats:p></jats:sec>