• Media type: E-Article
  • Title: Naturalistic use of psychedelics is related to emotional reactivity and self-consciousness: The mediating role of ego-dissolution and mystical experiences
  • Contributor: Orłowski, Paweł; Ruban, Anastasia; Szczypiński, Jan; Hobot, Justyna; Bielecki, Maksymilian; Bola, Michał
  • imprint: SAGE Publications, 2022
  • Published in: Journal of Psychopharmacology
  • Language: English
  • DOI: 10.1177/02698811221089034
  • ISSN: 0269-8811; 1461-7285
  • Keywords: Pharmacology (medical) ; Psychiatry and Mental health ; Pharmacology
  • Origination:
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  • Description: <jats:sec><jats:title>Background:</jats:title><jats:p> Psychedelics are able to acutely alter emotional reactivity and self-consciousness. However, whether the regular naturalistic use of psychedelics can be linked to more persistent trait-level changes in these domains remains an open question. </jats:p></jats:sec><jats:sec><jats:title>Aim:</jats:title><jats:p> To test the hypotheses that (1) using psychedelics is related to higher positive and lower negative emotional reactivity; and (2) an adaptive pattern of self-consciousness, including diminished public self-consciousness and rumination, and increased reflection and self-awareness; and (3) these relations are mediated by the intensity of past ego-dissolution and mystical experiences. </jats:p></jats:sec><jats:sec><jats:title>Method:</jats:title><jats:p> An online survey including questions about the history of psychoactive substance use; questionnaires measuring trait levels of emotional reactivity and self-consciousness; questionnaires for retrospective assessment of ego-dissolution and mystical experiences. Data collected from 2516 participants (1661 psychedelics users) were analyzed using robust linear regression and mediation analysis. </jats:p></jats:sec><jats:sec><jats:title>Results:</jats:title><jats:p> A higher number of lifetime uses of psychedelics predicted greater positive and lower negative emotional reactivity; also, in the domain of self-consciousness, it predicted greater reflection and internal state awareness, and reduced rumination tendency and public self-consciousness. Finally, the intensity of past mystical and ego-dissolution experiences mediated almost all the observed relationships between the lifetime number of psychedelics uses and psychological variables. </jats:p></jats:sec><jats:sec><jats:title>Conclusions:</jats:title><jats:p> Lifetime psychedelics use predicts an adaptive pattern of trait-level emotional reactivity and self-consciousness. Ego-dissolution and mystical experiences are essential in understanding the long-lasting psychological effects of psychedelics use. Our findings might potentially explain previous observations of increased well-being in psychedelics users. </jats:p></jats:sec>