Validation of ratings on the six-item Positive and Negative Syndrome Scale obtained via the Simplified Negative and Positive Symptoms Interview among outpatients with schizophrenia

Media type: E-Article
Title: Validation of ratings on the six-item Positive and Negative Syndrome Scale obtained via the Simplified Negative and Positive Symptoms Interview among outpatients with schizophrenia
Contributor: Nielsen, Cecilie Marie; Kølbæk, Pernille; Dines, David; Pedersen, Martin Locht; Danielsen, Andreas Aalkjær; Holmgård, Camilla; Wissing, Sanne; Esbøl, Anne-Mette; Fuglsang, Nina Friis Bak; Nguyen, Tuan Dang; Mors, Ole; Opler, Mark; Correll, Christoph U; Østergaard, Søren Dinesen
imprint: SAGE Publications, 2022
Published in: Journal of Psychopharmacology
Language: English
DOI: 10.1177/02698811221131992
ISSN: 0269-8811; 1461-7285
Keywords: Pharmacology (medical) ; Psychiatry and Mental health ; Pharmacology
Origination:
Footnote:
Description: <jats:sec><jats:title>Background:</jats:title><jats:p> The six-item Positive and Negative Syndrome Scale (PANSS-6) is a measure of the severity of core symptoms of schizophrenia, which can be administered via the brief Simplified Negative and Positive Symptoms Interview (SNAPSI). A recent study has confirmed the validity of PANSS-6 ratings as derived by SNAPSI (PANSS-6<jats:sub>SNAPSI</jats:sub>) among inpatients with schizophrenia. </jats:p></jats:sec><jats:sec><jats:title>Aims:</jats:title><jats:p> We aimed to test the validity of PANSS-6<jats:sub>SNAPSI</jats:sub> among outpatients with schizophrenia using PANSS-6 ratings extracted from the 30-item PANSS-30 as derived by the Structured Clinical Interview for the Positive and Negative Syndrome Scale (PANSS-6<jats:sub>SCI-PANSS</jats:sub>) as a gold standard reference. </jats:p></jats:sec><jats:sec><jats:title>Methods:</jats:title><jats:p> PANSS-6<jats:sub>SNAPSI</jats:sub> and PANSS-6<jats:sub>SCI-PANSS</jats:sub> ratings were obtained at two time points by independent raters with established inter-rater reliability. Agreement between PANSS-6<jats:sub>SNAPSI</jats:sub> and PANSS-6<jats:sub>SCI-PANSS</jats:sub> ratings was estimated via intra-class coefficients (ICCs) and responsiveness over time was quantified using Spearman’s rank correlation coefficients. Post hoc “leave-one-out” analyses were carried out, in which each rater in turn was excluded from the ICC calculations. </jats:p></jats:sec><jats:sec><jats:title>Results:</jats:title><jats:p> Seventy-three outpatients with schizophrenia participated in the study (mean age: 38.3 years; 56% males). The ICC for PANSS-6<jats:sub>SNAPSI</jats:sub> versus PANSS-6<jats:sub>SCI-PANSS</jats:sub> was 0.67 [95%CI = 0.56–0.76] and the Spearman’s rank correlation coefficient for responsiveness was 0.40 ( p = 0.004). When data from a specific outlying rater were excluded, the ICC for PANSS-6<jats:sub>SNAPSI</jats:sub> versus PANSS-6<jats:sub>SCI-PANSS</jats:sub> was 0.75 [95% CI = 0.63–0.83] and the Spearman’s rank correlation coefficient for responsiveness was 0.55 ( p = 0.018). </jats:p></jats:sec><jats:sec><jats:title>Conclusions:</jats:title><jats:p> We found PANSS-6<jats:sub>SNAPSI</jats:sub> ratings to have acceptable clinical validity, suggesting that PANSS-6<jats:sub>SNAPSI</jats:sub> can be used for both inpatients and outpatients with schizophrenia. </jats:p></jats:sec>

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