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Media type:
E-Article
Title:
Cholesterol Levels in Later Life Amongst UK Channel Islanders Exposed to the 1940–45 German Occupation as Children, Adolescents and Young Adults
Contributor:
Head, Rosemary F.;
Gilthorpe, Mark S.;
Ellison, George T.H.
Description:
<jats:p> Background: To clarify the nature of the relationship between: food deprivation and undernutrition during pre- and postnatal development; and cholesterol levels in later life, this study examined the relationship between birth weight (as a marker of prenatal nutrition) and cholesterol levels among 396 Guernsey islanders (born in 1923–1937), 87 of whom (22%) had been exposed to food deprivation as children, adolescents or young adults (i.e. to postnatal undernutrition) during the 1940–45 German occupation of the Channel Islands, and 309 of Whom (78%) had left or been evacuated from the islands before the occupation began. </jats:p><jats:p> Methods: Three sets of multiple regression models were used to investigate: Model A — the relationship between birth weight and cholesterol levels; Model B — the relationship between postnatal exposure to the occupation and cholesterol levels; and Model C — any interaction between birth weight, postnatal exposure to the occupation and cholesterol levels. Model A and Model B also tested for any interactions between: birth weight/occupation exposure and sex; and birth weight/occupation exposure and parish of residence at birth (as a marker of parish of residence during the occupation and related variation in the severity of food deprivation). </jats:p><jats:p> Results: Before (and after) adjusting for potential confounders, no statistically significant relationships were observed between either birth weight (before adjustment: 0.09mmol/1 per kg increase, 95% CI: −0.30, 0.16; after adjustment: 0.08mmol/1 per kg increase, 95%CI: −0.17, 0.34) or exposure to the occupation (before adjustment: 0.01 mmol/l for exposed group, 95%CI: −0.24, 0.27; after adjustment: 0.041llmol/1 for exposed group, 95%CI: −0.26, 0.33) and cholesterol levels in later life. There was also little evidence of significant relationships between birth weight, exposure to the occupation and cholesterol levels in later life when Model A and Model B were stratified by sex or parish of residence at birth, although there was a significant positive relationship between birth weight and cholesterol levels in women (0.44mmol/1 per kg increase, 95%CI: 0.07, 0.81). </jats:p><jats:p> Conclusions: These analyses provide little support for the theory that birth weight is inversely related to cholesterol levels in later life, and do not offer any evidence in support of a relationship between undernutrition in childhood, adolescence and early adulthood and cholesterol levels in later life. However, further research may determine whether undernutrition at different stages of the life-course may influence cholesterol levels in later life. </jats:p>