• Media type: E-Article
  • Title: Obstructive Colon Metastases from Lobular Breast Cancer: Report of a Case and Review of the Literature
  • Contributor: Mistrangelo, Massimiliano; Cassoni, Paola; Mistrangelo, Marinella; Castellano, Isabella; Codognotto, Elena; Sapino, Anna; Lamanna, Ginevra; Cravero, Francesca; Bianco, Lavinia; Fora, Gianluca; Sandrucci, Sergio
  • imprint: SAGE Publications, 2011
  • Published in: Tumori Journal
  • Language: English
  • DOI: 10.1177/030089161109700619
  • ISSN: 0300-8916; 2038-2529
  • Keywords: Cancer Research ; Oncology ; General Medicine
  • Origination:
  • Footnote:
  • Description: <jats:sec><jats:title>Introduction</jats:title><jats:p> Gastrointestinal metastases from breast cancer are rare. One large series reported a rate of 0.7% of gastrointestinal metastatic manifestations from breast cancer, but its true incidence could be underestimated. Here we report a case of bowel obstruction caused by sigmoid metastases from breast cancer and describe its relevance to histological origin and clinical practice. </jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p> The clinical course and histopathology of the case are reviewed and compared with reports of similar cases in the literature. </jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p> An 80-year-old woman presented with bowel obstruction. Her medical history included infiltrating lobular breast cancer treated with left radical mastectomy 25 years before the current presentation; 13 years later bone metastases developed and were treated with hormone therapy. In 2003 the patient came to our emergency department because of symptoms of bowel obstruction. A computed tomography (CT) scan revealed a mass in the distal sigmoid causing the obstruction. A colostomy was performed, followed by a second operation completed with Hartmann's procedure. Histological examination revealed metastases from invasive lobular carcinoma. The patient was discharged 45 days postoperatively and died 9 months later because of disease progression. </jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p> Although gastrointestinal metastases from breast cancer are rare, patients with diagnosed breast cancer, particularly invasive lobular carcinoma, should be regularly followed up with endoscopy, CT, endosonography and PET-CT when abdominal symptoms are present. This could permit early diagnosis of gastrointestinal metastases and improve treatment planning. </jats:p></jats:sec>