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Media type:
E-Article
Title:
Human Diurnal Preference and Circadian Rhythmicity Are Not Associated with the CLOCK 3111C/T Gene Polymorphism
Contributor:
Chang, Anne-Marie;
Buch, Alison M.;
Bradstreet, Dayna S.;
Klements, David J.;
Duffy, Jeanne F.
Published:
SAGE Publications, 2011
Published in:
Journal of Biological Rhythms, 26 (2011) 3, Seite 276-279
Language:
English
DOI:
10.1177/0748730411402026
ISSN:
0748-7304;
1552-4531
Origination:
Footnote:
Description:
Genetic association studies of the CLOCK 3111C/T polymorphism and diurnal preference have yielded conflicting results since the first report that the 3111C allele was associated with eveningness. The goal of the present study was to investigate the association of this polymorphism with diurnal preference and circadian physiology in a group of 179 individuals, by comparing the frequency of the 3111C allele to diurnal preference, habitual sleep timing, circadian phase markers, and circadian period. We did not find a significant association between this allele and morningness/eveningness or any circadian marker.