> Details

Upadhyaya, Santhosh A.; Koschmann, Carl; Muraszko, Karin; Venneti, Sriram; Garton, Hugh J.; Hamstra, Daniel A.; Maher, Cormac O.; Betz, Bryan L.; Brown, Noah A.; Wahl, Daniel; Weigelin, Helmut C.; DuRoss, Kathleen E.; Leonard, Annette S.; Robertson, Patricia L.

Brainstem Low-Grade Gliomas in Children—Excellent Outcomes With Multimodality Therapy

Reference
management

Bookmarks

Remove from
bookmarks

Share this on Whatsapp

Close

Bookmarks



You can manage bookmarks using lists, please log in to your user account for this.
  • Media type: E-Article
  • Title: Brainstem Low-Grade Gliomas in Children—Excellent Outcomes With Multimodality Therapy
  • Contributor: Upadhyaya, Santhosh A.; Koschmann, Carl; Muraszko, Karin; Venneti, Sriram; Garton, Hugh J.; Hamstra, Daniel A.; Maher, Cormac O.; Betz, Bryan L.; Brown, Noah A.; Wahl, Daniel; Weigelin, Helmut C.; DuRoss, Kathleen E.; Leonard, Annette S.; Robertson, Patricia L.
  • Published: SAGE Publications, 2017
  • Published in: Journal of Child Neurology, 32 (2017) 2, Seite 194-203
  • Language: English
  • DOI: 10.1177/0883073816675547
  • ISSN: 0883-0738; 1708-8283
  • Origination:
  • Footnote:
  • Description: Safe maximal surgical resection is the initial treatment of choice for pediatric brainstem low-grade gliomas. Optimal therapy for incompletely resected tumors or that progress after surgery is uncertain. We reviewed the clinical characteristics, therapy, and outcomes of all children with nontectal brainstem low-grade gliomas treated at the University of Michigan between 1993 and 2013. Median age at diagnosis was 6 years; histology was confirmed in 23 of 25 tumors, 64% were pilocytic astrocytoma. Nineteen patients underwent initial tumor resection; 14/19 received no upfront adjuvant therapy. Eight patients in the study had progressive disease; 5 initially resected tumors received chemotherapy at tumor relapse, all with partial or complete radiographic responses. Ten-year progression-free survival is 71% and overall survival, 100%. This single-institution retrospective study demonstrates excellent survival rates for children with brainstem low-grade gliomas. The efficacy of the well-tolerated chemotherapy in this series supports its role in the treatment of unresectable or progressive brainstem low-grade gliomas.