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Wei, Ying; Sun, Jiaxin; Su, Liya; Xu, Tunhai

Gentianella turkestanorum (Gand.) Holub, a Chinese Herbal Medicine that can Alleviate T2DM in Db/db Mice, and its Active Mechanism of Action

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  • Media type: E-Article
  • Title: Gentianella turkestanorum (Gand.) Holub, a Chinese Herbal Medicine that can Alleviate T2DM in Db/db Mice, and its Active Mechanism of Action
  • Contributor: Wei, Ying; Sun, Jiaxin; Su, Liya; Xu, Tunhai
  • Published: SAGE Publications, 2024
  • Published in: Pharmacognosy Magazine, 20 (2024) 2, Seite 646-655
  • Language: English
  • DOI: 10.1177/09731296231215577
  • ISSN: 0973-1296; 0976-4062
  • Origination:
  • Footnote:
  • Description: <jats:sec><jats:title>Background</jats:title><jats:p> The increasing prevalence of type 2 diabetes mellitus (T2DM) on a global scale has created a pressing demand for novel treatments. Gentianella turkestanorum (Gand.) Holub, a traditional Chinese herbal medicine, has been found to possess hypoglycemic effects. However, the mechanism of its action remains unclear. </jats:p></jats:sec><jats:sec><jats:title>Objectives</jats:title><jats:p> This study was to investigate the impact and mechanism of G. turkestanorum’s water extract (WEG) in reducing insulin resistance (IR) in T2DM. </jats:p></jats:sec><jats:sec><jats:title>Materials and Methods</jats:title><jats:p> Db/db mice were administered WEG for 8 weeks, during which their body weight, blood glucose (BG), oral glucose tolerance test, islet tolerance test, fasting insulin, total cholesterol, triglyceride, high-density lipoprotein, and low-density lipoprotein were monitored. Additionally, tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) levels in db/db mice were measured using enzyme-linked immunosorbent assay (ELISA). The study also evaluated the impact of WEG on liver injury through hematoxylin-eosin staining. The expression levels of key proteins and genes in both insulin signaling and inflammation-related pathways were detected using western blotting and real-time quantitative polymerase chain reaction. </jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p> WEG has the potential to regulate glycolipid metabolism, reduce inflammation, and alleviate IR. The mechanism of action may involve promoting the insulin signaling pathway and inhibiting inflammation. </jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p> Gentianella turkestanorum could be a viable treatment option for T2DM and IR. </jats:p></jats:sec>
  • Access State: Open Access