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Media type:
E-Article
Title:
Denosumab versus zoledronic acid in elderly patients after hip fracture
Contributor:
Kim, Seung-Ju;
Kim, Ji Woon;
Lee, Dong-Woo
Published:
SAGE Publications, 2022
Published in:
Journal of Orthopaedic Surgery, 30 (2022) 3
Language:
English
DOI:
10.1177/10225536221147082
ISSN:
1022-5536;
2309-4990
Origination:
Footnote:
Description:
Background Two injectable anti-osteoporosis medications, denosumab and zoledronic acid, have been widely used to treat patients with severe osteoporosis. The purpose of this study was to evaluate the real-world effectiveness and adherence of denosumab compared to zoledronic acid in geriatric patients after a hip fracture. Methods A total of 282 patients treated with osteoporotic hip fracture between March 2014 and Aug 2022 were retrospectively reviewed. The patients were asked to select the anti-osteoporosis medication after surgery. Treatment persistence was monitored by follow-up visit to the outpatient clinic at postoperative 2 years. Results Of 282 individuals with baseline data, 162 patients took subcutaneous denosumab and 120 patients took intravenous zoledronic acid. At postoperative 2 years, the change in bone mineral density (BMD) from baseline was greater in the denosumab group compared with the zoledronic acid group ( p < 0.001). The rate of persistence to denosumab was significantly higher than that for 12-months zoledronic acid ( p = 0.01). Serious adverse events were similar in the two groups. Conclusions Our study revealed the effectiveness and patients' persistence for two commonly used anti-osteoporosis agents after hip fracture. In this frail, elderly population, half-yearly denosumab was superior to yearly zoledronic acid in BMD and demonstrated significant higher persistence rate, indicating a potential therapeutic advantage that warrants further validation.