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Trang, Do Thi; Huyen, Le Thi; Nhiem, Nguyen Xuan; Quang, Tran Hong; Hang, Dan Thi Thuy; Yen, Pham Hai; Tai, Bui Huu; Anh, Hoang Le Tuan; Binh, Nguyen Quoc; Van Minh, Chau; Van Kiem, Phan

Tirucallane Glycoside from the Leaves of Antidesma bunius and Inhibitory NO Production in BV2 Cells and RAW264.7 Macrophages

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  • Media type: E-Article
  • Title: Tirucallane Glycoside from the Leaves of Antidesma bunius and Inhibitory NO Production in BV2 Cells and RAW264.7 Macrophages
  • Contributor: Trang, Do Thi; Huyen, Le Thi; Nhiem, Nguyen Xuan; Quang, Tran Hong; Hang, Dan Thi Thuy; Yen, Pham Hai; Tai, Bui Huu; Anh, Hoang Le Tuan; Binh, Nguyen Quoc; Van Minh, Chau; Van Kiem, Phan
  • imprint: SAGE Publications, 2016
  • Published in: Natural Product Communications
  • Language: English
  • DOI: 10.1177/1934578x1601100717
  • ISSN: 1934-578X; 1555-9475
  • Keywords: Complementary and alternative medicine ; Plant Science ; Drug Discovery ; Pharmacology ; General Medicine
  • Origination:
  • Footnote:
  • Description: <jats:p> One new tirucallane- type triterpene glycoside, antidesoside (1), along with two biflavones, podocarpusflavone A (2) and amentoflavone (3) and two megastigmane glycosides, byzantionoside B (4), and (6 S,9 R)-roseoside (5) were isolated from the methanol extract of Antidesma bunius leaves. Their structures were determined by spectroscopic methods and in comparison with the published data. Compounds 1 - 3 were found to show strong inhibitory effect of NO production in BV2 cells and RAW264.7 macrophages LPS-stimulated, with IC<jats:sub>50</jats:sub> values ranging from 8.5 to 26.9 μM. </jats:p>
  • Access State: Open Access