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Sainz de la Maza, Susana; Gómez-Ballesteros, Rocío; Borges, Mónica; Martín-Martínez, Jesús; Sotoca, Javier; Alonso, Ana; Caminero, Ana B; Borrega, Laura; Sánchez-Menoyo, José L; Barrero-Hernández, Francisco J; Calles, Carmen; Brieva, Luis; Blasco-Quílez, María R; Dotor García-Soto, Julio; Campo-Amigo, María del; Navarro-Cantó, Laura; Agüera, Eduardo; Garcés-Redondo, Moisés; Carmona, Olga; Gabaldón-Torres, Laura; Forero, Lucía; Hervàs, Mariona; Medrano, Nicolás; Maurino, Jorge;

Detecting disability using self-reported and clinical assessments in early-stage relapsing-remitting multiple sclerosis: Looking for a complementary approach

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  • Media type: E-Article
  • Title: Detecting disability using self-reported and clinical assessments in early-stage relapsing-remitting multiple sclerosis: Looking for a complementary approach
  • Contributor: Sainz de la Maza, Susana; Gómez-Ballesteros, Rocío; Borges, Mónica; Martín-Martínez, Jesús; Sotoca, Javier; Alonso, Ana; Caminero, Ana B; Borrega, Laura; Sánchez-Menoyo, José L; Barrero-Hernández, Francisco J; Calles, Carmen; Brieva, Luis; Blasco-Quílez, María R; Dotor García-Soto, Julio; Campo-Amigo, María del; Navarro-Cantó, Laura; Agüera, Eduardo; Garcés-Redondo, Moisés; Carmona, Olga; Gabaldón-Torres, Laura; Forero, Lucía; Hervàs, Mariona; Medrano, Nicolás; Maurino, Jorge;
  • imprint: SAGE Publications, 2023
  • Published in: Multiple Sclerosis Journal - Experimental, Translational and Clinical
  • Language: English
  • DOI: 10.1177/20552173231169475
  • ISSN: 2055-2173
  • Keywords: Cellular and Molecular Neuroscience ; Neurology (clinical)
  • Origination:
  • Footnote:
  • Description: <jats:p> Disability accrual is mainly driven by progression independent of relapse activity, which is present even in early stages of relapsing-remitting multiple sclerosis (RRMS) and sometimes overlooked. This multicenter, non-interventional study evaluated whether patient-reported outcomes measures (PROMs) could capture disability in 189 early-stage RRMS patients (mean age: 36.1 ± 9.4 years, 71.4% female, mean disease duration: 1.4 ± 0.8 years, median EDSS: 1.0). The 9-Hole Peg Test (9-HPT), NeuroQoL Upper Extremity (NeuroQoL-UE), Timed 25-Foot Walk (T25-FW), Multiple Sclerosis Walking Scale (MSWS-12), Symbol Digit Modalities Test (SDMT), and Perceived Deficits Questionnaire (PDQ-5) were used to assess hand function, gait, and cognition, respectively. These functions were at least mildly affected in this early-stage population, finding significant correlations between PROMs and clinical assessments. PROMs could enable early-stage RRMS patients to communicate their perceived disability in different domains, assisting clinicians in disease monitoring and decision making. </jats:p>
  • Access State: Open Access