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Media type:
E-Article
Title:
Complement-induced regulatory T cells suppress T-cell responses but allow for dendritic-cell maturation
Contributor:
Barchet, Winfried;
Price, Jeffrey D.;
Cella, Marina;
Colonna, Marco;
MacMillan, Sandra K.;
Cobb, J. Perren;
Thompson, Paul A.;
Murphy, Kenneth M.;
Atkinson, John P.;
Kemper, Claudia
Published:
American Society of Hematology, 2006
Published in:
Blood, 107 (2006) 4, Seite 1497-1504
Language:
English
DOI:
10.1182/blood-2005-07-2951
ISSN:
0006-4971;
1528-0020
Origination:
Footnote:
Description:
Concurrent activation of the T-cell receptor (TCR) and complement regulator CD46 on human CD4+ T lymphocytes induces Tr1-like regulatory T cells that suppress through IL-10 secretion bystander T-cell proliferation. Here we show that, despite their IL-10 production, CD46-induced T-regulatory T cells (Tregs) do not suppress the activation/maturation of dendritic cells (DCs). DC maturation by complement/CD46-induced Tregs is mediated through simultaneous secretion of GM-CSF and soluble CD40L, factors favoring DC differentiation and reversing inhibitory effects of IL-10. Thus, CD46-induced Tregs produce a distinct cytokine profile that inhibits T-cell responses but leaves DC activation unimpaired. Such “DC-sparing” Tregs could be desirable at host/environment interfaces such as the gastrointestinal tract where their specific cytokine profile provides a mechanism that ensures unresponsiveness to commensal bacteria while maintaining reactivity to invading pathogens.