> Details

Reichenbach, Dawn K.; Schwarze, Vincent; Matta, Benjamin M.; Tkachev, Victor; Lieberknecht, Elisabeth; Liu, Quan; Koehn, Brent H.; Pfeifer, Dietmar; Taylor, Patricia A.; Prinz, Gabriele; Dierbach, Heide; Stickel, Natalie; Beck, Yvonne; Warncke, Max; Junt, Tobias; Schmitt-Graeff, Annette; Nakae, Susumu; Follo, Marie; Wertheimer, Tobias; Schwab, Lukas; Devlin, Jason; Watkins, Simon C.; Duyster, Justus; Ferrara, James L. M.; [...]

The IL-33/ST2 axis augments effector T-cell responses during acute GVHD

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  • Media type: E-Article
  • Title: The IL-33/ST2 axis augments effector T-cell responses during acute GVHD
  • Contributor: Reichenbach, Dawn K.; Schwarze, Vincent; Matta, Benjamin M.; Tkachev, Victor; Lieberknecht, Elisabeth; Liu, Quan; Koehn, Brent H.; Pfeifer, Dietmar; Taylor, Patricia A.; Prinz, Gabriele; Dierbach, Heide; Stickel, Natalie; Beck, Yvonne; Warncke, Max; Junt, Tobias; Schmitt-Graeff, Annette; Nakae, Susumu; Follo, Marie; Wertheimer, Tobias; Schwab, Lukas; Devlin, Jason; Watkins, Simon C.; Duyster, Justus; Ferrara, James L. M.; [...]
  • imprint: American Society of Hematology, 2015
  • Published in: Blood
  • Language: English
  • DOI: 10.1182/blood-2014-10-606830
  • ISSN: 0006-4971; 1528-0020
  • Origination:
  • Footnote:
  • Description: <jats:title>Key Points</jats:title><jats:p>IL-33 and ST2 expression are increased post-conditioning and with GVHD, resulting in increased T-cell activation via the IL-33/ST2 axis. Infusion of ST2-Fc protein exploits sST2’s function as a negative regulator of acute GVHD inhibiting pro-inflammatory cytokines.</jats:p>
  • Access State: Open Access