• Media type: E-Article
  • Title: Hyperactive mTOR pathway promotes lymphoproliferation and abnormal differentiation in autoimmune lymphoproliferative syndrome
  • Contributor: Völkl, Simon; Rensing-Ehl, Anne; Allgäuer, Andrea; Schreiner, Elisabeth; Lorenz, Myriam Ricarda; Rohr, Jan; Klemann, Christian; Fuchs, Ilka; Schuster, Volker; von Bueren, André O.; Naumann-Bartsch, Nora; Gambineri, Eleonora; Siepermann, Kathrin; Kobbe, Robin; Nathrath, Michaela; Arkwright, Peter D.; Miano, Maurizio; Stachel, Klaus-Daniel; Metzler, Markus; Schwarz, Klaus; Kremer, Anita N.; Speckmann, Carsten; Ehl, Stephan; Mackensen, Andreas
  • Published: American Society of Hematology, 2016
  • Published in: Blood, 128 (2016) 2, Seite 227-238
  • Language: English
  • DOI: 10.1182/blood-2015-11-685024
  • ISSN: 0006-4971; 1528-0020
  • Origination:
  • Footnote:
  • Description: Key PointsALPS DNT cells and their putative precursors reveal high proliferative activity in vivo, which is associated with hyperactive mTOR signaling. Rapamycin therapy controls mitotic activity and abnormal differentiation of ALPS DNT cells and reduces CD4+ or CD8+ precursor DNT cells.
  • Access State: Open Access