Oppermann, Sina;
Ylanko, Jarkko;
Shi, Yonghong;
Hariharan, Santosh;
Oakes, Christopher C.;
Brauer, Patrick M.;
Zúñiga-Pflücker, Juan C.;
Leber, Brian;
Spaner, David E.;
Andrews, David W.
High-content screening identifies kinase inhibitors that overcome venetoclax resistance in activated CLL cells
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Media type:
E-Article
Title:
High-content screening identifies kinase inhibitors that overcome venetoclax resistance in activated CLL cells
Contributor:
Oppermann, Sina;
Ylanko, Jarkko;
Shi, Yonghong;
Hariharan, Santosh;
Oakes, Christopher C.;
Brauer, Patrick M.;
Zúñiga-Pflücker, Juan C.;
Leber, Brian;
Spaner, David E.;
Andrews, David W.
Published:
American Society of Hematology, 2016
Published in:
Blood, 128 (2016) 7, Seite 934-947
Language:
English
DOI:
10.1182/blood-2015-12-687814
ISSN:
0006-4971;
1528-0020
Origination:
Footnote:
Description:
<jats:title>Key Points</jats:title>
<jats:p>Patient-specific pathways of resistance to venetoclax can be identified by high-content screening of clinical samples with a KI library. Sunitinib may overcome resistance to venetoclax for many patients by downregulating the expression of Bcl-xl, Mcl-1, and A1 in CLL cells.</jats:p>