• Media type: E-Article
  • Title: Therapeutic potential of SGN-CD19B, a PBD-based anti-CD19 drug conjugate, for treatment of B-cell malignancies
  • Contributor: Ryan, Maureen C.; Palanca-Wessels, Maria Corinna; Schimpf, Brian; Gordon, Kristine A.; Kostner, Heather; Meyer, Brad; Yu, Changpu; Van Epps, Heather A.; Benjamin, Dennis
  • Published: American Society of Hematology, 2017
  • Published in: Blood, 130 (2017) 18, Seite 2018-2026
  • Language: English
  • DOI: 10.1182/blood-2017-04-779389
  • ISSN: 0006-4971; 1528-0020
  • Keywords: Cell Biology ; Hematology ; Immunology ; Biochemistry
  • Origination:
  • Footnote:
  • Description: <jats:title>Key Points</jats:title><jats:p>SGN-CD19B is broadly active in vitro against malignant B-cell lines, including double-hit and triple-hit lymphoma cell lines. SGN-CD19B shows significant antitumor activity in vivo in preclinical models of B-NHL and B-cell–derived acute lymphoblastic leukemia.</jats:p>
  • Access State: Open Access