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Haggenburg, Sabine; Lissenberg-Witte, Birgit I.; van Binnendijk, Rob S.; den Hartog, Gerco; Bhoekhan, Michel S.; Haverkate, Nienke J. E.; de Rooij, Dennis M.; van Meerloo, Johan; Cloos, Jacqueline; Kootstra, Neeltje A.; Wouters, Dorine; Weijers, Suzanne S.; van Leeuwen, Ester M. M.; Bontkes, Hetty J.; Tonouh-Aajoud, Saïda; Heemskerk, Mirjam H. M.; Sanders, Rogier W.; Roelandse-Koop, Elianne; Hofsink, Quincy; Groen, Kazimierz; Çetinel, Lucia; Schellekens, Louis; den Hartog, Yvonne M.; Toussaint, Belle; [...]

Quantitative analysis of mRNA-1273 COVID-19 vaccination response in immunocompromised adult hematology patients

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  • Media type: E-Article
  • Title: Quantitative analysis of mRNA-1273 COVID-19 vaccination response in immunocompromised adult hematology patients
  • Contributor: Haggenburg, Sabine; Lissenberg-Witte, Birgit I.; van Binnendijk, Rob S.; den Hartog, Gerco; Bhoekhan, Michel S.; Haverkate, Nienke J. E.; de Rooij, Dennis M.; van Meerloo, Johan; Cloos, Jacqueline; Kootstra, Neeltje A.; Wouters, Dorine; Weijers, Suzanne S.; van Leeuwen, Ester M. M.; Bontkes, Hetty J.; Tonouh-Aajoud, Saïda; Heemskerk, Mirjam H. M.; Sanders, Rogier W.; Roelandse-Koop, Elianne; Hofsink, Quincy; Groen, Kazimierz; Çetinel, Lucia; Schellekens, Louis; den Hartog, Yvonne M.; Toussaint, Belle; [...]
  • Published: American Society of Hematology, 2022
  • Published in: Blood Advances, 6 (2022) 5, Seite 1537-1546
  • Language: English
  • DOI: 10.1182/bloodadvances.2021006917
  • ISSN: 2473-9529; 2473-9537
  • Origination:
  • Footnote:
  • Description: <jats:title>Abstract</jats:title> <jats:p>Vaccination guidelines for patients treated for hematological diseases are typically conservative. Given their high risk for severe COVID-19, it is important to identify those patients that benefit from vaccination. We prospectively quantified serum immunoglobulin G (IgG) antibodies to spike subunit 1 (S1) antigens during and after 2-dose mRNA-1273 (Spikevax/Moderna) vaccination in hematology patients. Obtaining S1 IgG ≥ 300 binding antibody units (BAUs)/mL was considered adequate as it represents the lower level of S1 IgG concentration obtained in healthy individuals, and it correlates with potent virus neutralization. Selected patients (n = 723) were severely immunocompromised owing to their disease or treatment thereof. Nevertheless, &amp;gt;50% of patients obtained S1 IgG ≥ 300 BAUs/mL after 2-dose mRNA-1273. All patients with sickle cell disease or chronic myeloid leukemia obtained adequate antibody concentrations. Around 70% of patients with chronic graft-versus-host disease (cGVHD), multiple myeloma, or untreated chronic lymphocytic leukemia (CLL) obtained S1 IgG ≥ 300 BAUs/mL. Ruxolitinib or hypomethylating therapy but not high-dose chemotherapy blunted responses in myeloid malignancies. Responses in patients with lymphoma, patients with CLL on ibrutinib, and chimeric antigen receptor T-cell recipients were low. The minimal time interval after autologous hematopoietic cell transplantation (HCT) to reach adequate concentrations was &amp;lt;2 months for multiple myeloma, 8 months for lymphoma, and 4 to 6 months after allogeneic HCT. Serum IgG4, absolute B- and natural killer–cell number, and number of immunosuppressants predicted S1 IgG ≥ 300 BAUs/mL. Hematology patients on chemotherapy, shortly after HCT, or with cGVHD should not be precluded from vaccination. This trial was registered at Netherlands Trial Register as #NL9553.</jats:p>
  • Access State: Open Access