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Delgado-Ortiz, Laura; Ranciati, Saverio; Arbillaga-Etxarri, Ane; Balcells, Eva; Buekers, Joren; Demeyer, Heleen; Frei, Anja; Gimeno-Santos, Elena; Hopkinson, Nicholas S.; de Jong, Corina; Karlsson, Niklas; Louvaris, Zafeiris; Palmerini, Luca; Polkey, Michael I.; Puhan, Milo A.; Rabinovich, Roberto A.; Rodríguez Chiaradia, Diego A.; Rodriguez-Roisin, Robert; Toran-Montserrat, Pere; Vogiatzis, Ioannis; Watz, Henrik; Troosters, Thierry; Garcia-Aymerich, Judith

Real-world walking cadence in people with COPD

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  • Media type: E-Article
  • Title: Real-world walking cadence in people with COPD
  • Contributor: Delgado-Ortiz, Laura; Ranciati, Saverio; Arbillaga-Etxarri, Ane; Balcells, Eva; Buekers, Joren; Demeyer, Heleen; Frei, Anja; Gimeno-Santos, Elena; Hopkinson, Nicholas S.; de Jong, Corina; Karlsson, Niklas; Louvaris, Zafeiris; Palmerini, Luca; Polkey, Michael I.; Puhan, Milo A.; Rabinovich, Roberto A.; Rodríguez Chiaradia, Diego A.; Rodriguez-Roisin, Robert; Toran-Montserrat, Pere; Vogiatzis, Ioannis; Watz, Henrik; Troosters, Thierry; Garcia-Aymerich, Judith
  • Published: European Respiratory Society (ERS), 2024
  • Published in: ERJ Open Research, 10 (2024) 2, Seite 00673-2023
  • Language: English
  • DOI: 10.1183/23120541.00673-2023
  • ISSN: 2312-0541
  • Origination:
  • Footnote:
  • Description: IntroductionThe clinical validity of real-world walking cadence in people with COPD is unsettled. Our objective was to assess the levels, variability and association with clinically relevant COPD characteristics and outcomes of real-world walking cadence.MethodsWe assessed walking cadence (steps per minute during walking bouts longer than 10 s) from 7 days’ accelerometer data in 593 individuals with COPD from five European countries, and clinical and functional characteristics from validated questionnaires and standardised tests. Severe exacerbations during a 12-month follow-up were recorded from patient reports and medical registries.ResultsParticipants were mostly male (80%) and had mean±sdage of 68±8 years, post-bronchodilator forced expiratory volume in 1 s (FEV1) of 57±19% predicted and walked 6880±3926 steps·day−1. Mean walking cadence was 88±9 steps·min−1, followed a normal distribution and was highly stable within-person (intraclass correlation coefficient 0.92, 95% CI 0.90–0.93). After adjusting for age, sex, height and number of walking bouts in fractional polynomial or linear regressions, walking cadence was positively associated with FEV1,6-min walk distance, physical activity (steps·day−1, time in moderate-to-vigorous physical activity, vector magnitude units, walking time, intensity during locomotion), physical activity experience and health-related quality of life and negatively associated with breathlessness and depression (all p<0.05). These associations remained after further adjustment for daily steps. In negative binomial regression adjusted for multiple confounders, walking cadence related to lower number of severe exacerbations during follow-up (incidence rate ratio 0.94 per step·min−1, 95% CI 0.91–0.99, p=0.009).ConclusionsHigher real-world walking cadence is associated with better COPD status and lower severe exacerbations risk, which makes it attractive as a future prognostic marker and clinical outcome.
  • Access State: Open Access