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Wieczorek, Lindsay; Chang, David; Sanders-Buell, Eric; Zemil, Michelle; Martinez, Elizabeth; Schoen, Jesse; Chenine, Agnes-Laurence; Molnar, Sebastian; Barrows, Brittani; Poltavee, Kultida; Charurat, Man E.; Abimiku, Alash’le; Blattner, William; Iroezindu, Michael; Kokogho, Afoke; Michael, Nelson L.; Crowell, Trevor A.; Ake, Julie A.; Tovanabutra, Sodsai; Polonis, Victoria R.; Bartolanzo, Danielle; Reynolds, Alexus; Song, Katherine; Milazzo, Mark; [...]

Differences in neutralizing antibody sensitivities and envelope characteristics indicate distinct antigenic properties of Nigerian HIV-1 subtype G and CRF02_AG

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  • Media type: E-Article
  • Title: Differences in neutralizing antibody sensitivities and envelope characteristics indicate distinct antigenic properties of Nigerian HIV-1 subtype G and CRF02_AG
  • Contributor: Wieczorek, Lindsay; Chang, David; Sanders-Buell, Eric; Zemil, Michelle; Martinez, Elizabeth; Schoen, Jesse; Chenine, Agnes-Laurence; Molnar, Sebastian; Barrows, Brittani; Poltavee, Kultida; Charurat, Man E.; Abimiku, Alash’le; Blattner, William; Iroezindu, Michael; Kokogho, Afoke; Michael, Nelson L.; Crowell, Trevor A.; Ake, Julie A.; Tovanabutra, Sodsai; Polonis, Victoria R.; Bartolanzo, Danielle; Reynolds, Alexus; Song, Katherine; Milazzo, Mark; [...]
  • Published: Springer Science and Business Media LLC, 2024
  • Published in: Virology Journal, 21 (2024) 1
  • Language: English
  • DOI: 10.1186/s12985-024-02394-y
  • ISSN: 1743-422X
  • Origination:
  • Footnote:
  • Description: AbstractThe magnitude of the HIV-1 epidemic in Nigeria is second only to the subtype C epidemic in South Africa, yet the subtypes prevalent in Nigeria require further characterization. A panel of 50 subtype G and 18 CRF02_AG Nigerian HIV-1 pseudoviruses (PSV) was developed and envelope coreceptor usage, neutralization sensitivity and cross-clade reactivity were characterized. These PSV were neutralized by some antibodies targeting major neutralizing determinants, but potentially important differences were observed in specific sensitivities (eg. to sCD4, MPER and V2/V3 monoclonal antibodies), as well as in properties such as variable loop lengths, number of potential N-linked glycans and charge, demonstrating distinct antigenic characteristics of CRF02_AG and subtype G. There was preferential neutralization of the matched CRF/subtype when PSV from subtype G or CRF02_AG were tested using pooled plasma. These novel Nigerian PSV will be useful to study HIV-1 CRF- or subtype-specific humoral immune responses for subtype G and CRF02_AG.
  • Access State: Open Access