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Popescu, Cristina E.; Zhang, Boya; Sartoretti, Thomas; Spielhofer, Noel; Skawran, Stephan; Heimer, Jakob; Messerli, Michael; Sauter, Alexander; Huellner, Martin W.; Kaufmann, Philipp A.; Burger, Irene A.; Maurer, Alexander

Evaluating the biodistribution for [68Ga]Ga-PSMA-11 and [18F]F-PSMA-1007 PET/CT with an inter- and intrapatient based analysis

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  • Media type: E-Article
  • Title: Evaluating the biodistribution for [68Ga]Ga-PSMA-11 and [18F]F-PSMA-1007 PET/CT with an inter- and intrapatient based analysis
  • Contributor: Popescu, Cristina E.; Zhang, Boya; Sartoretti, Thomas; Spielhofer, Noel; Skawran, Stephan; Heimer, Jakob; Messerli, Michael; Sauter, Alexander; Huellner, Martin W.; Kaufmann, Philipp A.; Burger, Irene A.; Maurer, Alexander
  • Published: Springer Science and Business Media LLC, 2024
  • Published in: EJNMMI Research, 14 (2024) 1
  • Language: English
  • DOI: 10.1186/s13550-024-01097-3
  • ISSN: 2191-219X
  • Origination:
  • Footnote:
  • Description: <jats:title>Abstract</jats:title><jats:sec> <jats:title>Background</jats:title> <jats:p>Liver uptake in [<jats:sup>68</jats:sup>Ga]Ga-PSMA-11 PET is used as an internal reference in addition to clinical parameters to select patients for [<jats:sup>177</jats:sup>Lu]Lu-PSMA-617 radioligand therapy (RLT). Due to increased demand, [<jats:sup>68</jats:sup>Ga]Ga-PSMA-11 was replaced by [<jats:sup>18</jats:sup>F]F-PSMA-1007, a more lipophilic tracer with different biodistribution and splenic uptake was suggested as a new internal reference. We compared the intra-patient tracer distribution between [<jats:sup>68</jats:sup>Ga]Ga-PSMA-11 and [<jats:sup>18</jats:sup>F]F-PSMA-1007.</jats:p> </jats:sec><jats:sec> <jats:title>Methods</jats:title> <jats:p>Fifty patients who underwent PET examinations in two centers with both [<jats:sup>18</jats:sup>F]F-PSMA-1007 and [<jats:sup>68</jats:sup>Ga]Ga-PSMA-11 within one year were included. Mean standardized uptake values (SUV<jats:sub>mean</jats:sub>) were obtained for liver, spleen, salivary glands, blood pool, and bone. Primary tumor, local recurrence, lymph node, bone or visceral metastasis were also assessed for intra- and inter-individual comparison.</jats:p> </jats:sec><jats:sec> <jats:title>Results</jats:title> <jats:p>Liver SUV<jats:sub>mean</jats:sub> was significantly higher with [<jats:sup>18</jats:sup>F]F-PSMA-1007 (11.7 ± 3.9) compared to [<jats:sup>68</jats:sup>Ga]Ga-PSMA-11 (5.4 ± 1.7, <jats:italic>p</jats:italic> &lt; .05) as well as splenic SUV<jats:sub>mean</jats:sub> (11.2 ± 3.5 vs.8.1 ± 3.5, <jats:italic>p</jats:italic> &lt; .05). The blood pool was comparable between the two scans. Malignant lesions did not show higher SUV<jats:sub>mean</jats:sub> on [<jats:sup>18</jats:sup>F]F-PSMA-1007. Intra-individual comparison of liver uptake between the two scans showed a linear association for liver uptake with SUV<jats:sub>mean</jats:sub> [<jats:sup>68</jats:sup>Ga]Ga-PSMA-11 = 0.33 x SUV<jats:sub>mean</jats:sub> [<jats:sup>18</jats:sup>F]F-PSMA-1007 + 1.52 (<jats:italic>r</jats:italic> = .78, <jats:italic>p</jats:italic> &lt; .001).</jats:p> </jats:sec><jats:sec> <jats:title>Conclusion</jats:title> <jats:p>Comparing biodistribution of [<jats:sup>68</jats:sup>Ga]Ga and [<jats:sup>18</jats:sup>F]F tracers, liver uptake on [<jats:sup>68</jats:sup>Ga]Ga-PSMA-11 PET is the most robust internal reference value. Liver uptake of [<jats:sup>18</jats:sup>F]F-PSMA-1007 was significantly higher, but so was the splenic uptake. The strong intra-individual association of hepatic accumulation between the two scans may allow using of a conversion factor for [<jats:sup>18</jats:sup>F]F-PSMA-1007 as a basis for RLT selection.</jats:p> </jats:sec>
  • Access State: Open Access