Published:
Springer Science and Business Media LLC, 2020
Published in:
AMB Express, 10 (2020) 1
Language:
English
DOI:
10.1186/s13568-020-01117-0
ISSN:
2191-0855
Origination:
Footnote:
Description:
AbstractTrametes spec. laccase (EC 1.10.3.2.) mediates the oxidative coupling of 6-aminopenicillanic, 7-aminocephalosporanic, and 7-aminodesacetoxycephalosporanic acid with 2,5-dihydroxybenzoic acid derivatives to form new penicillin and cephalosporin structures, respectively. The heteromolecular hybrid dimers are formed by nuclear amination of the p-hydroquinones with the primary amines and inhibited in vitro the growth of Staphylococcus species, including some multidrug-resistant strains.