Talib, Hina;
Mehmood, Ansar;
Amjad, Muhammad Shoaib;
Mustafa, Amna;
Khan, Muhammad Abdul Rauf;
Raffi, Muhammad;
Khan, Rizwan Taj;
Ahmad, Khawaja Shafique;
Qureshi, Huma
Antibacterial, antioxidant, and anticancer potential of green fabricated silver nanoparticles made from Viburnum grandiflorum leaf extract
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Media type:
E-Article
Title:
Antibacterial, antioxidant, and anticancer potential of green fabricated silver nanoparticles made from Viburnum grandiflorum leaf extract
Contributor:
Talib, Hina;
Mehmood, Ansar;
Amjad, Muhammad Shoaib;
Mustafa, Amna;
Khan, Muhammad Abdul Rauf;
Raffi, Muhammad;
Khan, Rizwan Taj;
Ahmad, Khawaja Shafique;
Qureshi, Huma
Published:
Springer Science and Business Media LLC, 2024
Description:
<jats:title>Abstract</jats:title><jats:sec>
<jats:title>Background</jats:title>
<jats:p>Recently, researchers are focusing on creating new tools to combat the antibiotic resistant bacteria and malignancy issues, which pose significant threats to humanity. Biosynthesized silver nanoparticles (AgNPs) are thought to be a potential solution to these issues. The biosynthesis method, known for its environmentally friendly and cost-effective characteristics, can produce small-sized AgNPs with antimicrobial and anticancer properties. In this study, AgNPs were bio-fabricated from the distilled water and methanolic extracts of <jats:italic>Viburnum grandiflorum</jats:italic> leaves. Physio-chemical characterization of the bio-fabricated AgNPs was conducted using UV-visible spectroscopy, scanning electron microscopy, energy dispersive X-ray, and X-ray diffraction analysis.</jats:p>
</jats:sec><jats:sec>
<jats:title>Results</jats:title>
<jats:p>AgNPs produced from the methanol extract were smaller in size (12.28 nm) compared to those from the aqueous extract (17.77 nm). The bioengineered AgNPs exhibited a circular shape with a crystalline nature. These biosynthesized AgNPs demonstrated excellent bactericidal activity against both gram-negative (<jats:italic>Pseudomonas aeruginosa</jats:italic>) and gram-positive (<jats:italic>Staphylococcus aureus</jats:italic>) bacteria. Highest antibacterial activity was observed with the methanol extract against <jats:italic>P. aeruginosa</jats:italic> (14.66 ± 0.74 mm). AgNPs from the methanol extract also displayed the highest antioxidant activity, with an IC<jats:sub>50</jats:sub> value of 188.00 ± 2.67 μg/mL against 2,2-diphenyl-1-picrylhydrazyl (DPPH). Furthermore, AgNPs exhibited notable cytotoxic activity against Rhabdomyosarcoma cell line (RD cell) of human muscle cancer cell. The IC<jats:sub>50</jats:sub> values calculated from the MTT assay were 26.28 ± 1.58 and 21.49 ± 1.44 μg/mL for AgNPs synthesized from aqueous and methanol extracts, respectively.</jats:p>
</jats:sec><jats:sec>
<jats:title>Conclusion</jats:title>
<jats:p>The methanol extract of <jats:italic>V. grandiflorum</jats:italic> leaves demonstrates significant potential for synthesizing AgNPs with effective antibacterial, antioxidant, and anticancer actions, making them applicable in various biomedical applications.</jats:p>
</jats:sec>