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AbdelMassih, Antoine Fakhry; AbdelAzeam, Aisha Said; Ayad, Aya; Kamel, Aya Yasser; Khalil, Ayah; Kotb, Basma; Waheed, Dina; Menshawey, Esraa; Sefein, Fady; Taha, Farah; Ismail, Habiba-Allah; Osman, Ibrahim; Iskander, John; El Wakil, Lama; Rashad, Lara; Arsanyous, Mariem Badr; El Shershaby, Meryam; Mansour, Mina; Ashraf, Mirette; Hafez, Nada; Abuzeid, Nadeen Mohamed; AbdElSalam, Noheir Mahmoud-Nashaat; Hafez, Nouran Gamal; Youssef, Nourhan; [...]

Unleashing the mysterious link between COVID-19 and a famous childhood vasculitis: Kawasaki disease

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  • Media type: E-Article
  • Title: Unleashing the mysterious link between COVID-19 and a famous childhood vasculitis: Kawasaki disease
  • Contributor: AbdelMassih, Antoine Fakhry; AbdelAzeam, Aisha Said; Ayad, Aya; Kamel, Aya Yasser; Khalil, Ayah; Kotb, Basma; Waheed, Dina; Menshawey, Esraa; Sefein, Fady; Taha, Farah; Ismail, Habiba-Allah; Osman, Ibrahim; Iskander, John; El Wakil, Lama; Rashad, Lara; Arsanyous, Mariem Badr; El Shershaby, Meryam; Mansour, Mina; Ashraf, Mirette; Hafez, Nada; Abuzeid, Nadeen Mohamed; AbdElSalam, Noheir Mahmoud-Nashaat; Hafez, Nouran Gamal; Youssef, Nourhan; [...]
  • imprint: Springer Science and Business Media LLC, 2020
  • Published in: Egyptian Pediatric Association Gazette
  • Language: English
  • DOI: 10.1186/s43054-020-00029-9
  • ISSN: 2090-9942
  • Keywords: Environmental Engineering
  • Origination:
  • Footnote:
  • Description: <jats:title>Abstract</jats:title><jats:sec> <jats:title>Background</jats:title> <jats:p>Coronavirus disease 2019 (COVID-19) emerged as a small outbreak in Wuhan rapidly progressing into the deadliest pandemic since the Spanish flu of 1918. The disease was deemed trivial in children, until the reporting, few days ago, of an emerging pediatric multi-inflammatory syndrome mimicking Kawasaki disease (KD).</jats:p> </jats:sec><jats:sec> <jats:title>Main body</jats:title> <jats:p>This report reveals that coronaviridae were implicated in induction of several post-infectious vasculitides, namely, KD, AHEI, and HSP. This occurs in genetically susceptible individuals to vascular inflammation. Shared genetic susceptibilities between KD and CoV include genes encoding for CD 40, HLAB-15:03, and ACE. This leads to augmented inflammation with hypersecretion of cytokines especially IL-6.</jats:p> </jats:sec><jats:sec> <jats:title>Conclusion</jats:title> <jats:p>The revealed relationships between KD and CoV can help to predict the risk of KD in COVID-19 patients through screening levels of upregulated cytokines. It might also signify that classic treatment of KD with IVIG might need to be replaced with anti-cytokine therapy in COVID-19 patients.</jats:p> </jats:sec>