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Media type:
E-Article
Title:
Enhancement of the Prolactin Response to d-Fenfluramine in Drug-Naive Schizophrenic Patients
Contributor:
Abel, Kathryn M.;
O'Keane, Veronica;
Murray, Robin M.
Published:
Royal College of Psychiatrists, 1996
Published in:
British Journal of Psychiatry, 168 (1996) 1, Seite 57-60
Language:
English
DOI:
10.1192/bjp.168.1.57
ISSN:
0007-1250;
1472-1465
Origination:
Footnote:
Description:
BackgroundWe wished to investigate central serotonergic function in untreated schizophrenia.MethodThirteen drug-naive, DSM–III–R schizophrenic patients were compared with sex, race, age, weight and menstrual phase matched controls. Plasma prolactin and cortisol responses to a specific serotonergic probe, d-fenfluramine, were measured along with BPRS ratings.ResultsProlactin responses were enhanced in schizophrenic patients compared to controls (P < 0.05) and were correlated positively with BPRS items for depression, anxiety and guilt. Baseline cortisol was also raised in those with schizophrenia (P < 0.001).ConclusionsCentral serotonergic tone may be raised in acute, drug-naive schizophrenia and may be associated with the presence of affective symptomatology.