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Media type:
E-Article
Title:
Shared polygenic contribution between childhood attention-deficit hyperactivity disorder and adult schizophrenia
Contributor:
Hamshere, Marian L.;
Stergiakouli, Evangelia;
Langley, Kate;
Martin, Joanna;
Holmans, Peter;
Kent, Lindsey;
Owen, Michael J.;
Gill, Michael;
Thapar, Anita;
O'Donovan, Mick;
Craddock, Nick
imprint:
Royal College of Psychiatrists, 2013
Published in:British Journal of Psychiatry
Language:
English
DOI:
10.1192/bjp.bp.112.117432
ISSN:
0007-1250;
1472-1465
Origination:
Footnote:
Description:
<jats:sec><jats:title>Background</jats:title><jats:p>There is recent evidence of some degree of shared genetic susceptibility between adult schizophrenia and childhood attention-deficit hyperactivity disorder (ADHD) for rare chromosomal variants.</jats:p></jats:sec><jats:sec><jats:title>Aims</jats:title><jats:p>To determine whether there is overlap between common alleles conferring risk of schizophrenia in adults with those that do so for ADHD in children.</jats:p></jats:sec><jats:sec><jats:title>Method</jats:title><jats:p>We used recently published Psychiatric Genome-wide Association Study (GWAS) Consortium (PGC) adult schizophrenia data to define alleles over-represented in people with schizophrenia and tested whether those alleles were more common in 727 children with ADHD than in 2067 controls.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Schizophrenia risk alleles discriminated ADHD cases from controls (<jats:italic>P</jats:italic> = 1.04 × 10<jats:sup>4</jats:sup>, <jats:italic>R</jats:italic><jats:sup>2</jats:sup> = 0.45%); stronger discrimination was given by alleles that were risk alleles for both adult schizophrenia and adult bipolar disorder (also derived from a PGC data-set) (<jats:italic>P</jats:italic> = 9.98 ×10<jats:sup>−6</jats:sup>, <jats:italic>R</jats:italic><jats:sup>2</jats:sup> × 0.59%).</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>This increasing evidence for a small, but significant, shared genetic susceptibility between adult schizophrenia and childhood ADHD highlights the importance of research work across traditional diagnostic boundaries.</jats:p></jats:sec>